2007
Activated Insulin-Reactive CD8 T cells in NOD mice Cause Diabetes. (129.46)
Wong F, Siew L, Thomas I, Chapman S, Viret C, Wen L. Activated Insulin-Reactive CD8 T cells in NOD mice Cause Diabetes. (129.46). The Journal Of Immunology 2007, 178: s227-s227. DOI: 10.4049/jimmunol.178.supp.129.46.Peer-Reviewed Original ResearchCD8 T cellsTCR transgenic miceT cellsTransgenic miceNOD miceCD8 T cell clonesPredominance of CD8TCR transgenic cellsCD4 T cellsT cell clonesSingle-positive thymocytesT cell selectionSpontaneous diabetesAdoptive transferPeripheral lymphClonotypic TCRNaïve phenotypeCause diabetesDiabetesPositive thymocytesInsulin peptidesMiceCell clonesActivationCells
2002
Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide
Moriyama H, Wen L, Abiru N, Liu E, Yu L, Miao D, Gianani R, Wong F, Eisenbarth G. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 5539-5544. PMID: 11943868, PMCID: PMC122805, DOI: 10.1073/pnas.082120099.Peer-Reviewed Original ResearchConceptsT lymphocytesB7-1 transgenic miceBALB/c miceAnti-islet autoimmunityExperimental autoimmune diabetesAutoreactive T lymphocytesB7-1 moleculeCD4 T lymphocytesType 1 diabetesPolyinosinic-polycytidylic acidAutoimmune diabetesInsulin autoantibodiesC micePeptide immunizationSimultaneous administrationDisease inductionMurine modelMouse modelDiabetesTransgenic miceInsulin peptidesMiceImmunizationPolyICViral mimic