γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells
Pao W, Wen L, Smith A, Gulbranson-Judge A, Zheng B, Kelsoe G, MacLennan I, Owen M, Hayday A. γδ T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. Current Biology 1996, 6: 1317-1325. PMID: 8939571, DOI: 10.1016/s0960-9822(02)70718-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibodies, ProtozoanB-LymphocytesCD4 AntigensCoccidiosisEimeriaGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGerminal CenterImmunity, CellularImmunoglobulin GMiceMice, Mutant StrainsReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes, Helper-InducerConceptsGamma delta T cellsDelta T cellsT cell-B cell collaborationT cell helpT cell-deficient miceCell-deficient miceGamma delta cellsT cellsCell helpB cellsGerminal centersParasitic infectionsCell collaborationAlpha beta T cellsBeta T cellsT cell deficiencyDelta cellsDevelopment of autoimmunityAntibody levelsMycobacterial antigensCell deficiencyImmune responseAnatomical focusImmune systemAntibody specificityGerminal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Journal Of Experimental Medicine 1996, 183: 2271-2282. PMID: 8642336, PMCID: PMC2192585, DOI: 10.1084/jem.183.5.2271.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesClone CellsFlow CytometryGerminal CenterHumansImmunoglobulin Class SwitchingImmunoglobulin EImmunoglobulin GLupus Erythematosus, SystemicLymphocyte DepletionMiceMice, Inbred NODMice, Inbred StrainsMice, KnockoutMice, SCIDReceptors, Antigen, T-Cell, alpha-betaSpleenT-LymphocytesConceptsSystemic lupus erythematosusBeta T cellsAlpha/beta T cellsGamma/delta T cellsDelta T cellsT cell helpT cellsT cell receptorCell helpT cell-mediated conditionsHuman systemic lupus erythematosusSevere combined immunodeficient (SCID) miceDevelopment of autoantibodiesCombined Immunodeficient MiceT-cell immunodeficiencyClass-switched antibodiesB cell collaborationGerminal center formationLupus erythematosusAutoantibody productionLymphoid folliclesImmunoglobulin class switchingIgE synthesisAlpha/betaCell immunodeficiency