2017
Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery
Xu L, Cooper RC, Wang J, Yeudall WA, Yang H. Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery. ACS Biomaterials Science & Engineering 2017, 3: 1641-1653. PMID: 29147682, PMCID: PMC5683721, DOI: 10.1021/acsbiomaterials.7b00166.Peer-Reviewed Original ResearchStrain-promoted azide-alkyne cycloadditionAzide-alkyne cycloadditionDegree of PEGylationCross-linked networkDBCO groupsBioorthogonal chemistryDendrimer generationPEG spacerDrug deliveryChain lengthGeneration 4.0Sustained releaseHigh cytocompatibilityLocal drug deliveryPEG-BALoading densityDibenzocyclooctyneAnticancer drugsHydrogelsPhysical propertiesStructural parametersDendrimersBisazideChemistryCycloaddition
2015
Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug
Zolotarskaya OY, Xu L, Valerie K, Yang H. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Advances 2015, 5: 58600-58608. PMID: 26640689, PMCID: PMC4669072, DOI: 10.1039/c5ra07987j.Peer-Reviewed Original ResearchCamptothecin prodrugEfficient click chemistryAnionic polyamidoamine dendrimersSustained drug deliveryClick synthesisClick chemistryClick reactionCoupling reactionMultifunctional dendrimersFree CPTPolyamidoamine dendrimersReaction efficiencyDrug deliveryMethyl-morpholinium chlorideDendrimersCPT conjugatesSlow releaseDimethyl sulfoxideAgent 4PropargylaminesChemistrySynthesisReactionDose-dependent toxicityHuman glioma cells
2014
Semi-Interpenetrating Network (sIPN) Co-Electrospun Gelatin/Insulin Fiber Formulation for Transbuccal Insulin Delivery
Xu L, Sheybani N, Ren S, Bowlin GL, Yeudall WA, Yang H. Semi-Interpenetrating Network (sIPN) Co-Electrospun Gelatin/Insulin Fiber Formulation for Transbuccal Insulin Delivery. Pharmaceutical Research 2014, 32: 275-285. PMID: 25030186, DOI: 10.1007/s11095-014-1461-9.Peer-Reviewed Original ResearchConceptsMechanical propertiesPEG-DAModerate degradation rateDegradation ratePolyethylene glycol diacrylateScaffold formulationsFiber formulationsGlycol diacrylateSuitable formulationRelease kineticsSignificant enhancementSIPNsEosin YDrug deliveryInsulin deliveryNew formulationFormulationPermeabilityPropertiesCytocompatibilityFibersOil Red O stainingTransbuccal drug deliveryMethodsGelatinRed O staining