Tert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy
Guan L, Viswanathan V, Jiang Y, Vijayakumar S, Cao H, Zhao J, Colburg D, Neuhöfer P, Zhang Y, Wang J, Xu Y, Laseinde E, Hildebrand R, Rahman M, Frock R, Kong C, Beachy P, Artandi S, Le Q. Tert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy. Genes & Development 2024, 38: 569-582. PMID: 38997156, PMCID: PMC11293384, DOI: 10.1101/gad.351577.124.Peer-Reviewed Original ResearchConceptsSubmandibular glandSalivary gland homeostasisProgenitor cellsGland homeostasisResponse to radiotherapyAdult submandibular glandCell survivalSalivary gland regenerationSelf-renewal capacityEnhanced proliferative activityRadiation therapyDuctal regionsRadiotherapyModulate cell survivalTelomerase-expressingGland regenerationProliferative activityMouse strainsTERT expressionCreERT2 recombinaseSalivary gland biologyRadiation exposureTERT locusIn vitro cultureCell populationsAbstract 5442: Terthighcells: key players in salivary gland homeostasis and regeneration after radiation therapy in adult mice
Guan L, Viswanathan V, V S, Cao H, Jiang Y, Zhao J, Colburg D, Neuhoefer P, Xu Y, Laseinde E, Artandi S, Le Q. Abstract 5442: Terthighcells: key players in salivary gland homeostasis and regeneration after radiation therapy in adult mice. Cancer Research 2024, 84: 5442-5442. DOI: 10.1158/1538-7445.am2024-5442.Peer-Reviewed Original ResearchSalivary gland homeostasisSubmandibular glandRadiation therapyGland homeostasisDuctal regionsAdult miceAmerican Association for Cancer Research annual meetingsProgenitor cellsAcinar cellsRadiation cell killingAdult submandibular glandCell survivalSelf-renewal capacityPost-radiotherapyPost-radiationModulate cell survivalStem/progenitor cellsNormal organsMouse strainsTERT expressionCell killingDuctal cellsOxidative stress response pathwayCreERT2 recombinaseTERT locus