Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children
Wagar LE, Bolen CR, Sigal N, Angel C, Guan L, Kirkpatrick BD, Haque R, Tibshirani RJ, Parsonnet J, Petri WA, Davis MM. Increased T Cell Differentiation and Cytolytic Function in Bangladeshi Compared to American Children. Frontiers In Immunology 2019, 10: 2239. PMID: 31620139, PMCID: PMC6763580, DOI: 10.3389/fimmu.2019.02239.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsYears of ageIL-8Immune cellsPMA-ionomycinInfection-related morbidityIncidence of allergyBlood mononuclear cellsCytokine production profileT cell differentiationYears of lifeHygiene hypothesisImmune monitoringCytolytic functionMononuclear cellsHigh-income countriesImmune responseBangladeshi childrenMicrobial exposureAmerican childrenTGFβ expressionInfectious agentsImmune systemClinical healthAltered activation