2006
Mapping the Binding Site on CD8β for MHC Class I Reveals Mutants with Enhanced Binding
Devine L, Thakral D, Nag S, Dobbins J, Hodsdon ME, Kavathas PB. Mapping the Binding Site on CD8β for MHC Class I Reveals Mutants with Enhanced Binding. The Journal Of Immunology 2006, 177: 3930-3938. PMID: 16951356, DOI: 10.4049/jimmunol.177.6.3930.Peer-Reviewed Original ResearchConceptsMHC class IClass IT cellsT cell responsesEffective immune responseT cell recognitionT cell hybridomasT cell membraneImmune responseCoreceptor functionCell responsesCell hybridomasInfected cellsCell recognitionIdentified mutationsCD8alphaCoreceptorCD8betaCDR3 loopsCellsEnhanced bindingCD8ImmunotherapyCD8alphabetaCD8β
2004
Location of the epitope for an anti-CD8α antibody 53.6.7 which enhances CD8α-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation
Devine L, Hodsdon ME, Daniels MA, Jameson SC, Kavathas PB. Location of the epitope for an anti-CD8α antibody 53.6.7 which enhances CD8α-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation. Immunology Letters 2004, 93: 123-130. PMID: 15158607, DOI: 10.1016/j.imlet.2004.02.002.Peer-Reviewed Original ResearchAnimalsAntibodies, MonoclonalAntibody AffinityAntibody SpecificityBiotinylationCD8 AntigensChlorocebus aethiopsCOS CellsEgg ProteinsEpitope MappingEscherichia coliFlow CytometryH-2 AntigensHistocompatibility Antigens Class IMiceModels, MolecularMutagenesis, Site-DirectedOligopeptidesOvalbuminPeptide FragmentsProtein BindingProtein ConformationTransfection