2008
Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination
Thakral D, Dobbins J, Devine L, Kavathas PB. Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination. The Journal Of Immunology 2008, 180: 7431-7442. PMID: 18490743, DOI: 10.4049/jimmunol.180.11.7431.Peer-Reviewed Original ResearchConceptsCytoplasmic tailSplice variantsExpression patternsCell surfaceDifferent cytoplasmic tailsGene splice variantsMRNA expression patternsMRNA levelsFluorescent chimerasHuman genesHuman lineageDifferential mRNA expression patternsHeterodimer functionsExtracellular domainLysine residuesQuantitative RT-PCRDifferential expressionLysosomal compartmentTCR complexFunctional significanceIsoformsCD8B geneUbiquitinationCell linesPrimary humanDifferential Expression of Human CD8 Beta‐chain Isoforms and Regulation of M‐2 Isoform (splice variant 1) by Ubiquitination
Thakral D, Dobbins J, Devine L, Kavathas P. Differential Expression of Human CD8 Beta‐chain Isoforms and Regulation of M‐2 Isoform (splice variant 1) by Ubiquitination. The FASEB Journal 2008, 22: 367-367. DOI: 10.1096/fasebj.22.2_supplement.367.Peer-Reviewed Original ResearchCytoplasmic tailCell surfaceDifferent cytoplasmic tailsMRNA expression patternsMurine geneMRNA levelsFluorescent chimerasDifferential mRNA expression patternsExpression patternsExtracellular domainQuantitative RT-PCRDifferential expressionLysine residuesDifferential regulationUbiquitinationLysosomal compartmentSplice variantsTCR complexIsoformsT cell receptorPrimary human CD8CD8B geneMRNA patternsCell linesGenes
1996
SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics
Greenwood J, Pryce G, Devine L, Male D, dos Santos W, Calder V, Adamson P. SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics. Journal Of Neuroimmunology 1996, 71: 51-63. PMID: 8982103, DOI: 10.1016/s0165-5728(96)00130-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingAntigens, SurfaceBiological TransportBlood-Brain BarrierCell Adhesion MoleculesCell MovementCell Transformation, ViralEndotheliumEndothelium, VascularFluorescent Antibody Technique, IndirectHistocompatibility AntigensLipoproteins, LDLPigment Epithelium of EyeRatsRetinaSimian virus 40T-LymphocytesConceptsRetinal pigment epitheliumBlood-retinal barrierRetinal endotheliumAdhesion moleculesCell adhesion moleculeCell linesAntigen-specific T cell linesImmortalised cell linesMajor histocompatibility complex class 1Vascular cell adhesion moleculeRat brain endotheliumMHC class IIEndothelial cell adhesion moleculesIntercellular adhesion moleculeCentral nervous systemLectin Griffonia simplicifoliaPlatelet endothelial cell adhesion moleculeHigh-affinity uptakeT cell linesPigmented epithelial cellsRPE cell lineVon Willebrand factorEndothelial cell lineNeural parenchymaBrain endotheliumLymphocyte Migration across the Anterior and Posterior Blood–Retinal Barrierin Vitro
Devine L, Lightman S, Greenwood J. Lymphocyte Migration across the Anterior and Posterior Blood–Retinal Barrierin Vitro. Cellular Immunology 1996, 168: 267-275. PMID: 8640874, DOI: 10.1006/cimm.1996.0075.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensArrestinBlood-Retinal BarrierCell AdhesionCell LineChemotaxis, LeukocyteEndothelium, VascularEye ProteinsInterferon-gammaInterleukin-1Lymph NodesLymphocyte ActivationLymphocyte SubsetsMuromonab-CD3OvalbuminPigment Epithelium of EyeRatsRats, Inbred LewRats, Inbred StrainsReceptor-CD3 Complex, Antigen, T-CellRecombinant ProteinsRetinal VesselsSpecific Pathogen-Free OrganismsT-Lymphocytes, Helper-InducerTuberculinConceptsAntigen-specific T cell linesRat retinal pigment epitheliumBlood-retinal barrierT cell linesPLN cellsEndothelial cellsLymphocyte migrationPeripheral lymph node cellsCell linesRetinal vascular endotheliumLymph node cellsCross-linking CD3Migration of lymphocytesRetinal endothelial cellsRetinal pigment epitheliumCombination of CD3PVG ratsRetinal endotheliumIFN-gamma activationLewis ratsNode cellsS-antigenICAM-1IFN-gammaPigment epithelium