2015
Ion Channels Are Membrane Proteins
Levitan I, Kaczmarek L. Ion Channels Are Membrane Proteins. 2015, 85-102. DOI: 10.1093/med/9780199773893.003.0005.ChaptersMembrane-spanning segmentsHomologous domainsPrimary subunitIon channelsFunctional potassium channelsPotassium channelsVoltage-dependent ion channelsThree-dimensional structureMembrane proteinsSodium channelsMutational analysisProtein regionsVoltage-gated sodiumChannel proteinsChannel gatingProtein conformationStructural modulesChannel poreGlobal changeVoltage-dependent activationVoltage-dependent channelsSubunitsProteinOverall structureIon selectivitySynaptic Release of Neurotransmitters
Levitan I, Kaczmarek L. Synaptic Release of Neurotransmitters. 2015, 187-212. DOI: 10.1093/med/9780199773893.003.0009.ChaptersSynaptic vesiclesIndividual synaptic vesiclesRapid synaptic transmissionGenetic experimentsVoltage-dependent channelsEntry of calciumAmount of transmitterRelease of neurotransmittersSquid stellate ganglionFrog neuromuscular junctionNeurotransmitter releasePhysiological experimentsStellate ganglionSpecific synapsesSpecialized synapsesSynaptic transmissionSynaptic releaseRepetitive stimulationVesiclesPresynaptic terminalsNeuromuscular junctionAction potentialsFurther insightNeurotransmittersExocytosis
2008
Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission
Nanou E, Kyriakatos A, Bhattacharjee A, Kaczmarek LK, Paratcha G, Manira A. Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 20941-20946. PMID: 19095801, PMCID: PMC2634910, DOI: 10.1073/pnas.0806403106.Peer-Reviewed Original Research
2005
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels
Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing Research 2005, 206: 133-145. PMID: 16081004, DOI: 10.1016/j.heares.2004.11.023.Peer-Reviewed Original ResearchConceptsAnteroventral cochlear nucleusPotassium channelsAuditory pathwayAction potentialsCentral auditory pathwayVoltage-dependent potassium channelsMammalian auditory pathwayAmount of neurotransmitterProtein phosphorylationMNTB neuronsGene expressionBushy cellsPrincipal neuronsTrapezoid bodyCochlear nucleusIntrinsic excitabilityMedial nucleusVoltage-dependent channelsFiring patternsNeuronsAmplitude of currentsKv1 familySound stimuliLong-term modulationSound localization
2004
The Appearance of a Protein Kinase A-regulated Splice Isoform of slo Is Associated with the Maturation of Neurons That Control Reproductive Behavior*
Zhang Y, Joiner WJ, Bhattacharjee A, Rassendren F, Magoski NS, Kaczmarek LK. The Appearance of a Protein Kinase A-regulated Splice Isoform of slo Is Associated with the Maturation of Neurons That Control Reproductive Behavior*. Journal Of Biological Chemistry 2004, 279: 52324-52330. PMID: 15375169, DOI: 10.1074/jbc.m408543200.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAnimalsAplysiaCell DifferentiationCHO CellsCricetinaeCyclic AMP-Dependent Protein KinasesDNA, ComplementaryIn Vitro TechniquesLarge-Conductance Calcium-Activated Potassium ChannelsMolecular Sequence DataNeuronsPatch-Clamp TechniquesPotassium Channels, Calcium-ActivatedProtein IsoformsRecombinant ProteinsReproductionConceptsBag cell neuronsReproductive behaviorSlo geneConsensus phosphorylation sitesCell cDNA libraryProtein kinase ACell neuronsChinese hamster ovary cellsPhosphorylation sitesCatalytic subunitHamster ovary cellsAlternative transcriptsCDNA librarySplice isoformsKinase ABK channel activityMaturation of neuronsPKA inhibitorVoltage-dependent channelsOvary cellsBrief synaptic stimulationChannel activityMature neuronsIsoformsPKA
1990
Estrogen induction of a small, putative K+ channel mRNA in rat uterus
Pragnell M, Snay K, Trimmer J, MacLusky N, Naftolin F, Kaczmarek L, Boyle M. Estrogen induction of a small, putative K+ channel mRNA in rat uterus. Neuron 1990, 4: 807-812. PMID: 2344412, DOI: 10.1016/0896-6273(90)90207-v.Peer-Reviewed Original ResearchConceptsMRNA speciesAmino acid proteinProkaryotic ion channelsDramatic long-term changesMolecular cloningAcid proteinIon channel expressionMammalian sourcesIon channelsXenopus oocytesVoltage-dependent channelsSpeciesStructural motifsCritical roleChannel expressionMRNAChannel mRNAEstrogen inductionLong-term changesInductionCloningProteinMotifRegulationOocytes