2001
Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels*
Joiner W, Khanna R, Schlichter L, Kaczmarek L. Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels*. Journal Of Biological Chemistry 2001, 276: 37980-37985. PMID: 11495911, DOI: 10.1074/jbc.m104965200.Peer-Reviewed Original ResearchConceptsChannel assemblyC-terminusAssembly of channelsIon channelsC-terminal domainDistal C-terminal domainCo-immunoprecipitation experimentsCaM-binding domainSurface expressionDominant negative effectProximal C-terminusWhole-cell currentsCellular functionsCaM genesPlasma membraneCaM proteinFree CaMNovel mechanismTraffickingProteinTerminusAssemblyExpressionSK4Domain
1999
hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes ROLES IN PROLIFERATION AND VOLUME REGULATION*
Khanna R, Chang M, Joiner W, Kaczmarek L, Schlichter L. hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes ROLES IN PROLIFERATION AND VOLUME REGULATION*. Journal Of Biological Chemistry 1999, 274: 14838-14849. PMID: 10329683, DOI: 10.1074/jbc.274.21.14838.Peer-Reviewed Original ResearchConceptsIK currentsActivated T cell functionSecondary immune responseNaive T cellsT cell functionPromising therapeutic targetChinese hamster ovary cellsHamster ovary cellsHuman T lymphocytesVolume regulationKCa channelsT cellsT lymphocytesImmune responseTherapeutic targetIK blockHSK4Accessory moleculesHuman T lymphoblastsOvary cellsDistal C-terminusPharmacological propertiesT lymphoblastsCell functionProximal C-terminus