Endogenous parathyroid hormone-related protein functions as a neuroprotective agent
Chatterjee O, Nakchbandi IA, Philbrick WM, Dreyer BE, Zhang J, Kaczmarek LK, Brines ML, Broadus AE. Endogenous parathyroid hormone-related protein functions as a neuroprotective agent. Brain Research 2002, 930: 58-66. PMID: 11879796, DOI: 10.1016/s0006-8993(01)03407-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCalcium ChannelsCells, CulturedCerebral CortexDose-Response Relationship, DrugExcitatory Amino Acid AgonistsFemaleInjections, IntraperitonealKainic AcidL-Lactate DehydrogenaseMiceMice, KnockoutNeuroblastomaNeuronsNeuroprotective AgentsParathyroid Hormone-Related ProteinPatch-Clamp TechniquesPregnancyProteinsConceptsL-type voltage-sensitive calcium channelsCalcium channelsHippocampal c-Fos expressionVoltage-sensitive calcium channelsKainic acid-induced excitotoxicityCerebral cortical culturesFunction of PTHrPKainic acid excitotoxicityL-type calcium channelsCultured cerebellar granule cellsSensitive calcium channelsHormone-related proteinCentral nervous systemWhole-cell techniqueC-fos expressionCultured mouse neuroblastoma cellsCerebellar granule cellsMouse neuroblastoma cellsKainate toxicityCerebral cortexNeuroprotective agentsKainic acidLittermate miceCortical culturesPTHrP functions