2013
Expression of Kv1.3 potassium channels regulates density of cortical interneurons
Duque A, Gazula V, Kaczmarek LK. Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Developmental Neurobiology 2013, 73: 841-855. PMID: 23821603, PMCID: PMC3829632, DOI: 10.1002/dneu.22105.Peer-Reviewed Original ResearchConceptsKv1.3 geneMembrane-spanning channelsKv1.3-/- miceVasoactive intestinal peptideEffect of deletionCerebral cortexKv1.3 potassium channelsNeuropeptide YNeuronal differentiationKv1.3 proteinOlfactory bulbInterneuron populationsSelective poresExpression of Kv1.3Large familyCell membraneKv channelsNumber of calbindinNormal cortical functionWhole cerebral cortexWild-type miceKv1.3GenesDetection of odorsPotassium channels
2010
Kv1.3 is the exclusive voltage‐gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count
McCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut‐Smith M. Kv1.3 is the exclusive voltage‐gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count. The Journal Of Physiology 2010, 588: 1399-1406. PMID: 20308249, PMCID: PMC2876798, DOI: 10.1113/jphysiol.2010.188136.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PlateletsCalcium SignalingCell SizeDNA, ComplementaryHumansIn Vitro TechniquesKv1.3 Potassium ChannelMegakaryocytesMembrane PotentialsMiceMice, Inbred C57BLPatch-Clamp TechniquesPlatelet CountReverse Transcriptase Polymerase Chain ReactionScorpion VenomsSecond Messenger SystemsConceptsLarge ionic conductanceMembrane potentialHuman plateletsKv alphaMegakaryocyte developmentAncillary subunitsQuantitative RT-PCRMolecular levelKv channelsRole of Kv1.3MegakaryocytesKv1.3RT-PCRWild-type miceKv currentsSubunitsSignalingMiceApoptosisMargatoxinPlatelet activationRoleIonic conductancesPlateletsActivation