2018
C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity
Khare S, Galeano K, Zhang Y, Nick JA, Nick HS, Subramony SH, Sampson J, Kaczmarek LK, Waters MF. C-terminal proline deletions in KCNC3 cause delayed channel inactivation and an adult-onset progressive SCA13 with spasticity. The Cerebellum 2018, 17: 692-697. PMID: 29949095, PMCID: PMC8299775, DOI: 10.1007/s12311-018-0950-5.Peer-Reviewed Original ResearchConceptsIon channel functionMammalian cell cultureMutant proteinsIntracellular cSpinocerebellar ataxia 13Autosomal dominant neurological diseaseChannel functionAllelic heterogeneityProline deletionSCA13 patientsTerminal portionProgressive clinical symptomsNormal membranesCell culturesProteinElectrophysiological characterizationChannel inactivationInactivationClinical symptomsElectrophysiological profileNeurological diseasesClinical importanceSCA13Slow inactivationDeletion
1984
A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
Kaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsCyclic AMP analoguePotassium currentOutward currentsNormal ionic mediumOnset of afterdischargePhosphodiesterase-resistant cAMP analoguePeak inward currentsAMP analogueBag cell clustersDelayed potassium currentMinority of cellsSpontaneous dischargeCalcium currentPeptidergic neuronsVoltage-clamp analysisCell culturesTwo-electrode voltage clampInward currentsSodium currentNegative slope resistanceA-currentMarked reductionNeurons
1980
Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture
Kaczmarek LK, Jennings KR, Strumwasser F, Nairn AC, Walter U, Wilson FD, Greengard P. Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1980, 77: 7487-7491. PMID: 6261262, PMCID: PMC350530, DOI: 10.1073/pnas.77.12.7487.Peer-Reviewed Original ResearchConceptsCalcium action potentialsBag cell neuronsAction potentialsCell neuronsInput resistanceCalcium antagonistsControl injectionsIntracellular injectionAbdominal ganglionPotassium channelsProtein kinaseNeuronsPrimary culturesInjected cellsInjectionIntracellular microinjectionMembrane potentialSubthreshold oscillationsAMP-dependent protein kinaseMicroinjectionCell culturesCyclic AMP-dependent protein kinaseSpike enhancementCatalytic subunitExtracellular medium
1979
The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell culture
Kaczmarek L, Finbow M, Revel J, Strumwasser F. The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell culture. Developmental Neurobiology 1979, 10: 535-550. PMID: 521813, DOI: 10.1002/neu.480100604.Peer-Reviewed Original ResearchConceptsBag cell clustersBag cellsAbdominal ganglionLucifer YellowConnective tissueBag cell afterdischargeCell clustersSynchronous action potentialsIntracellular injectionIntact gangliaAction potentialsGangliaPrimary culturesNeurosecretory cellsDistal processesInjected cellsAfterdischargesCell actionGap junctionsSomaDye transferCellsPairs of cellsCell culturesCell processes