Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial.
Buckley L, Leib E, Cartularo K, Vacek P, Cooper S. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. Annals Of Internal Medicine 1996, 125: 961-8. PMID: 8967706, DOI: 10.7326/0003-4819-125-12-199612150-00004.Peer-Reviewed Original ResearchConceptsBone mineral densityLow-dose corticosteroidsPlacebo-controlled trialVitamin D3 supplementationMineral densityRheumatoid arthritisVitamin D3Prednisone therapyLumbar spineD3 supplementationBone lossOutpatient care facilitiesLong-term useCorticosteroid useVertebral fracturesWard's triangleAutoimmune diseasesFemoral neckCorticosteroidsHigh riskSupplemental calciumRational therapyPatientsArthritisTherapy