Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis
Wang H, Du Y, Huang S, Sun X, Ye Y, Sun H, Chu X, Shan X, Yuan Y, Shen L, Bi Y. Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis. Nature Communications 2024, 15: 4827. PMID: 38844451, PMCID: PMC11156882, DOI: 10.1038/s41467-024-48914-w.Peer-Reviewed Original ResearchConceptsAdipose progenitor cellsT2D patientsProgenitor cellsDiphtheria toxin A expressionHeterogeneous stromal cellsGlycemic disturbancesAdipose tissueInfluence of obesityGlucose homeostasisVisceral adipose tissueHuman visceral adipose tissueImpaired glucose homeostasisType 2 diabetesHunter-killer peptidesRegulating glucose homeostasisSingle-cell analysisAPC functionStromal cellsA expressionMetabolic homeostasisAdipocyte lipolysisT2D developmentPatientsT2DBioactive proteins