2024
Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis
Wang H, Du Y, Huang S, Sun X, Ye Y, Sun H, Chu X, Shan X, Yuan Y, Shen L, Bi Y. Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis. Nature Communications 2024, 15: 4827. PMID: 38844451, PMCID: PMC11156882, DOI: 10.1038/s41467-024-48914-w.Peer-Reviewed Original ResearchConceptsAdipose progenitor cellsT2D patientsProgenitor cellsDiphtheria toxin A expressionHeterogeneous stromal cellsGlycemic disturbancesAdipose tissueInfluence of obesityGlucose homeostasisVisceral adipose tissueHuman visceral adipose tissueImpaired glucose homeostasisType 2 diabetesHunter-killer peptidesRegulating glucose homeostasisSingle-cell analysisAPC functionStromal cellsA expressionMetabolic homeostasisAdipocyte lipolysisT2D developmentPatientsT2DBioactive proteins
2023
Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus
Tang W, Ge K, Shen L, Wang H, Feng W, Sun X, Chu X, Zhu D, Yin H, Bi Y. Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus. Diabetes/Metabolism Research And Reviews 2023, 39: e3620. PMID: 36738300, DOI: 10.1002/dmrr.3620.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes Mellitus, Type 2GluconeogenesisHumansInterleukin-17LiverMucosal-Associated Invariant T CellsTumor Necrosis Factor-alphaConceptsHepatic MAIT cellsMAIT cellsMAIT cell subsetsType 2 diabetes mellitusInnate-like T cell subsetMucosal-associated invariant T (MAIT) cellsHepatic gluconeogenesisMucosal-associated invariant T cellsExpression of pyruvate carboxylaseGene expression of pyruvate carboxylaseCell subsetsExpression of genesT2DM subjectsInvariant T cellsIFN-gMAIT cell frequencyPyruvate carboxylaseProduction of interleukin-17HepG2 cells co-culturedT cell subsetsTumor necrosis factor-aDevelopment of type 2 diabetes mellitusGene expressionDiagnosed T2DM subjectsMetabolic homoeostasis