Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors
Lin S, Dai Y, Han C, Han T, Zhao L, Wu R, Liu J, Zhang B, Huang N, Liu Y, Lai S, Shi J, Wang Y, Lou M, Xie J, Cheng Y, Tang H, Yao H, Fang H, Zhang Y, Wu X, Shen L, Ye Y, Xue L, Wu Z. Single-cell transcriptomics reveal distinct immune-infiltrating phenotypes and macrophage–tumor interaction axes among different lineages of pituitary neuroendocrine tumors. Genome Medicine 2024, 16: 60. PMID: 38658971, PMCID: PMC11040908, DOI: 10.1186/s13073-024-01325-4.Peer-Reviewed Original ResearchConceptsTumor immune microenvironmentTumor-associated macrophagesTumor cell apoptosisTumor cellsImmune cellsNeuroendocrine tumorsQuantitative immunofluorescenceComposition of immune cellsInfiltration of immune cellsMultiplexed quantitative immunofluorescenceLevel of immune infiltrationScRNA-seqPituitary neuroendocrine tumorsCX3CR1+ macrophagesDiversity of tumorsCell apoptosisSignificance of macrophagesRNA sequencing samplesScRNA-seq dataCX3CR1+Subcutaneous xenograft experimentsImmune microenvironmentSingle-cell RNA sequencingImmunological environmentImmune infiltration