Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus
Tang W, Ge K, Shen L, Wang H, Feng W, Sun X, Chu X, Zhu D, Yin H, Bi Y. Th1 bias of liver mucosal‐associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus. Diabetes/Metabolism Research And Reviews 2023, 39: e3620. PMID: 36738300, DOI: 10.1002/dmrr.3620.Peer-Reviewed Original ResearchConceptsHepatic MAIT cellsMAIT cellsMAIT cell subsetsType 2 diabetes mellitusInnate-like T cell subsetMucosal-associated invariant T (MAIT) cellsHepatic gluconeogenesisMucosal-associated invariant T cellsExpression of pyruvate carboxylaseGene expression of pyruvate carboxylaseCell subsetsExpression of genesT2DM subjectsInvariant T cellsIFN-gMAIT cell frequencyPyruvate carboxylaseProduction of interleukin-17HepG2 cells co-culturedT cell subsetsTumor necrosis factor-aDevelopment of type 2 diabetes mellitusGene expressionDiagnosed T2DM subjectsMetabolic homoeostasis