2024
Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice
Qi Q, Zhang H, Jin Z, Wang C, Xia M, Chen B, Lv B, Peres Diaz L, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L, Schneeberger M, Yu X. Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice. Nature Metabolism 2024, 6: 1601-1615. PMID: 39030389, DOI: 10.1038/s42255-024-01068-x.Peer-Reviewed Original ResearchConceptsHost metabolismGLP-1 productionGut microbiotaUnfolded protein responseMicrobiota-derived metabolitesIntestinal L cellsInhibit mitochondrial respirationDiet-induced metabolic disordersGut hormone glucagon-like peptide 1Hormone glucagon-like peptide 1Intestinal symbiontsProtein responseGLP-1Male miceGLP-1 secretionMitochondrial respirationGene expressionL cellsGutGlucagon-like peptide 1Production of hydrogen sulfideMicrobiotaPathogenesis of metabolic syndromeGLP-1 levelsDesulfovibrio
2021
Impact of structured basic life-support course on nurses' cardiopulmonary resuscitation knowledge and skills: Experience of a paediatric department in low-resource country
Umuhoza C, Chen L, Unyuzumutima J, McCall N. Impact of structured basic life-support course on nurses' cardiopulmonary resuscitation knowledge and skills: Experience of a paediatric department in low-resource country. African Journal Of Emergency Medicine 2021, 11: 366-371. PMID: 34367898, PMCID: PMC8327485, DOI: 10.1016/j.afjem.2021.03.014.Peer-Reviewed Original ResearchCentre Hospitalier Universitaire de KigaliOne-rescuer CPRInvestigational Review BoardPediatric departmentCardiopulmonary resuscitation knowledgePublic tertiary care hospitalNurses' baseline knowledgeTertiary level public hospitalTertiary care hospitalPediatric Nurses' KnowledgeBLS trainingBag-mask deviceLow-resource countriesBaseline knowledgeEducational intervention studyBasic life support trainingLife support courseLife support trainingBasic life support courseCare hospitalNurses' knowledgeResuscitation knowledgeEthical approvalAdvanced nursing degreesIntervention studiesHigh Hopes for Very Preterm Infants in Neonatal Intensive Care Units in China
Soma G, Chen L. High Hopes for Very Preterm Infants in Neonatal Intensive Care Units in China. JAMA Network Open 2021, 4: e2113649. PMID: 34137833, DOI: 10.1001/jamanetworkopen.2021.13649.Peer-Reviewed Original ResearchEvaluation of a Focused Cardiac Ultrasound Protocol in a Pediatric Emergency Department.
Riera A, Weeks B, Emerson BL, Chen L. Evaluation of a Focused Cardiac Ultrasound Protocol in a Pediatric Emergency Department. Pediatric Emergency Care 2021, 37: 191-198. PMID: 29746359, DOI: 10.1097/PEC.0000000000001495.Peer-Reviewed Original ResearchAgreement With Pediatric Suprapatellar Bursa Effusion Assessments by Point-of-Care Ultrasound After Remote Training
Riera A, Leviter JI, Iqbal A, Soma G, Malik RN, Chen L. Agreement With Pediatric Suprapatellar Bursa Effusion Assessments by Point-of-Care Ultrasound After Remote Training. Pediatric Emergency Care 2021, 38: e746-e751. PMID: 34542989, DOI: 10.1097/pec.0000000000002341.Peer-Reviewed Original ResearchConceptsReceiver operator characteristic curveKnee radiographyPediatric emergency medicine (PEM) fellowsOperator characteristic curveNovice sonologistsInterobserver reliabilityEffusion assessmentCare ultrasoundPredictive valuePediatric emergency departmentCharacteristic curveNegative predictive valuePositive predictive valuePediatric emergency medicineSubstantial interobserver reliabilityPediatric patientsEffusion sizeEmergency departmentMean ageAsymptomatic kneesMAIN OUTCOMEEffusionΚ coefficientPatientsTest characteristics
2020
Sound and Air
Hossain R, Qadri U, Dembowski N, Garcia A, Chen L, Cicero MX, Riera A. Sound and Air. Pediatric Emergency Care 2020, 37: e1544-e1548. PMID: 32925707, DOI: 10.1097/pec.0000000000002112.Peer-Reviewed Original ResearchConceptsAnterior axillary lineChest wall thicknessAxillary lineMidclavicular lineAnatomic sitesAdvanced Trauma Life SupportTrauma Life SupportInterclass correlation coefficientPediatric patientsPediatric guidelinesTension pneumothoracesEmergency departmentNeedle decompressionTension pneumothoraxCare ultrasoundPleural linePatientsWeight categoriesLife supportRight sideConvenience sampleInterrater reliabilityDecompressionSignificant differencesCatheterBarriers to childhood immunization in sub-Saharan Africa: A systematic review.
Bangura JB, Xiao S, Qiu D, Ouyang F, Chen L. Barriers to childhood immunization in sub-Saharan Africa: A systematic review. BMC Public Health 2020, 20: 1108. PMID: 32664849, PMCID: PMC7362649, DOI: 10.1186/s12889-020-09169-4.Peer-Reviewed Original ResearchAccuracy of Remote Interpretation of Pediatric Emergency Ultrasound Over Third Generation Networks Across Continents.
Whitney RE, Riera A, Chen L. Accuracy of Remote Interpretation of Pediatric Emergency Ultrasound Over Third Generation Networks Across Continents. Pediatric Emergency Care 2020, 36: e340-e342. PMID: 31851076, DOI: 10.1097/PEC.0000000000001948.Peer-Reviewed Original Research
2019
Incidence and Imminence of Pregnancy in At-Risk Teens After Emergency Department Visits.
Smith AL, Chen L. Incidence and Imminence of Pregnancy in At-Risk Teens After Emergency Department Visits. Pediatric Emergency Care 2019, 35: 837-839. PMID: 31790072, DOI: 10.1097/PEC.0000000000001989.Peer-Reviewed Original ResearchReevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients
Riera A, Hayward H, Silva C, Chen L. Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients. Pediatric Emergency Care 2019, 37: e1012-e1019. PMID: 31356479, DOI: 10.1097/pec.0000000000001877.Peer-Reviewed Original ResearchConceptsBlunt abdominal trauma patientsAbdominal trauma patientsFree fluidTrauma patientsUpper quadrantPredictive valueLevel I pediatric trauma centerPediatric trauma centerRetrospective chart reviewRight upper quadrantFAST examinationNegative predictive valuePositive predictive valueNegative likelihood ratioChart reviewBAT patientsMedian ageTrauma centerUpper abdomenIntraperitoneal fluidMAIN OUTCOMEPhysiologic amountsTrauma (FAST) examinationPatientsFocused assessment
2018
Reasons for parental withdrawal of care in a pediatric intensive care unit in China
Ho K, Wang X, Chen L. Reasons for parental withdrawal of care in a pediatric intensive care unit in China. PLOS ONE 2018, 13: e0199419. PMID: 30044777, PMCID: PMC6059386, DOI: 10.1371/journal.pone.0199419.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitIntensive care unitClinical improvementCare unitDisease severityNon-withdrawal groupMean hospital chargesDay of deathICU stayHospital stayHospital chargesWithdrawal groupMedical costsMedical carePatientsCareSubstantial proportionAdmissionStaySubstantial numberSeverityLower disease severityFinancial hardshipLarge proportionDays
2017
“What do you know?”——knowledge among village doctors of lead poisoning in children in rural China
Huang R, Ning H, Baum CR, Chen L, Hsiao A. “What do you know?”——knowledge among village doctors of lead poisoning in children in rural China. BMC Public Health 2017, 17: 895. PMID: 29169343, PMCID: PMC5701361, DOI: 10.1186/s12889-017-4895-2.Peer-Reviewed Original ResearchConceptsVillage doctorsLead poisoningResultsA totalMultifaceted interventionsBackgroundThis studyPrevention strategiesCollege-level educationConclusionsThis studyLevel educationPoor knowledgeRural childrenPrevention measuresChildrenDoctorsQuestionnaire-based surveyPoisoningRural ChinaRural populationTest questionnaireClear needQuestionnaireAnnual incomeMethodsA
2016
Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED
Whitney RE, Santucci K, Hsiao A, Chen L. Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED. The American Journal Of Emergency Medicine 2016, 34: 1573-1575. PMID: 27289438, DOI: 10.1016/j.ajem.2016.05.075.Peer-Reviewed Original ResearchConceptsAcute gastroenteritisPediatric emergency department (ED) visitsPOC testingEmergency department visitsLength of stayCost of admissionRandomized control trialChemistry testingCost-effective analysisDecision analysis modelCare testingDepartment visitsPediatric EDElectrolyte testingAdmission ratesSerum testingClinical assessmentControl trialMean savingsDegree of dehydrationPatientsCost savingsChildrenTrialsPayersReliability of Telemedicine in the Assessment of Seriously Ill Children.
Siew L, Hsiao A, McCarthy P, Agarwal A, Lee E, Chen L. Reliability of Telemedicine in the Assessment of Seriously Ill Children. Pediatrics 2016, 137: e20150712. PMID: 26908666, DOI: 10.1542/peds.2015-0712.Peer-Reviewed Original Research
2013
Pediatric emergency medicine fellow training in ultrasound: consensus educational guidelines.
Vieira RL, Hsu D, Nagler J, Chen L, Gallagher R, Levy JA. Pediatric emergency medicine fellow training in ultrasound: consensus educational guidelines. Academic Emergency Medicine : Official Journal Of The Society For Academic Emergency Medicine 2013, 20: 300-6. PMID: 23517263, DOI: 10.1111/acem.12087.Peer-Reviewed Original Research
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosisUltrasound Evaluation of Skull Fractures in Children
Riera A, Chen L. Ultrasound Evaluation of Skull Fractures in Children. Pediatric Emergency Care 2012, 28: 420-425. PMID: 22531195, DOI: 10.1097/pec.0b013e318252da3b.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolDiagnosis, DifferentialFeasibility StudiesFemaleFollow-Up StudiesHumansInfantInfant, NewbornMalePilot ProjectsPoint-of-Care SystemsPredictive Value of TestsProspective StudiesROC CurveSkull FracturesTomography, X-Ray ComputedTrauma Severity IndicesUltrasonographyConceptsAcute closed head injuryClosed head injurySkull fractureBedside ultrasoundPediatric emergency medicineCT scanUrban tertiary care children's hospitalPredictive valueTertiary care children's hospitalTest characteristicsUnnecessary CT scansClinical decision rulePediatric emergency departmentEmergency medicineComputed tomography scanNegative predictive valuePositive predictive valueMonths of trainingMedian ageChildren's HospitalUltrasound evaluationEmergency departmentHead injuryBedside ultrasonographyTomography scanDiagnosis of Intussusception by Physician Novice Sonographers in the Emergency Department
Riera A, Hsiao AL, Langhan ML, Goodman TR, Chen L. Diagnosis of Intussusception by Physician Novice Sonographers in the Emergency Department. Annals Of Emergency Medicine 2012, 60: 264-268. PMID: 22424652, PMCID: PMC3431911, DOI: 10.1016/j.annemergmed.2012.02.007.Peer-Reviewed Original ResearchConceptsPediatric emergency physiciansIleocolic intussusceptionEmergency physiciansUltrasonographic resultsUrban tertiary care children's hospitalPredictive valueBedside emergency department ultrasonographyTertiary care children's hospitalEmergency department ultrasonographyDiagnosis of intussusceptionProspective convenience sample studyLikelihood ratioNegative predictive valuePositive predictive valueConvenience sample studyBowel ultrasonographyMedian agePediatric EDChildren's HospitalUltrasonographic studyEmergency departmentObservational studyPhysician sonographersBedside studiesIntussusception
2010
Use of Bedside Ultrasound to Assess Degree of Dehydration in Children With Gastroenteritis
Chen L, Hsiao A, Langhan M, Riera A, Santucci KA. Use of Bedside Ultrasound to Assess Degree of Dehydration in Children With Gastroenteritis. Academic Emergency Medicine 2010, 17: 1042-1047. PMID: 21040104, PMCID: PMC3058669, DOI: 10.1111/j.1553-2712.2010.00873.x.Peer-Reviewed Original ResearchMeSH KeywordsAortaChildChild, PreschoolCohort StudiesDehydrationDiarrheaEmergency Service, HospitalFemaleFluid TherapyGastroenteritisHemodynamicsHumansInfantInfusions, IntravenousLinear ModelsMaleObserver VariationPilot ProjectsPoint-of-Care SystemsProspective StudiesReproducibility of ResultsSeverity of Illness IndexUltrasonography, DopplerVena Cava, InferiorConceptsInferior vena cavaIVC/Ao ratioPediatric emergency departmentAo diametersAcute gastroenteritisAo ratioBedside ultrasound measurementAcute weight lossProspective observational studyResolution of symptomsAorta diameter ratioAcute care settingInterrater reliabilityPairs of investigatorsPearson correlation coefficientSignificant dehydrationGood interrater reliabilityEmergency departmentIntravascular volumeBedside USVena cavaBedside ultrasoundObservational studyCare settingsProspective identification
2008
Randomized Trial of Endotracheal Tube Versus Laryngeal Mask Airway in Simulated Prehospital Pediatric Arrest
Chen L, Hsiao AL. Randomized Trial of Endotracheal Tube Versus Laryngeal Mask Airway in Simulated Prehospital Pediatric Arrest. Pediatrics 2008, 122: e294-e297. PMID: 18644845, DOI: 10.1542/peds.2008-0103.Peer-Reviewed Original ResearchConceptsLaryngeal mask airwayMask airwayEndotracheal tubePrehospital providersEffective ventilationPediatric arrestsLaryngeal mask airway groupEndotracheal tube groupMain-stem intubationNew airway devicesEmergency medical techniciansAirway groupCardiopulmonary arrestCrossover studyRandomized trialsAirway devicesAirway managementTube groupSuccessful ventilationHuman patient simulatorEsophageal intubationAirwayMean differenceMedical techniciansArrest scenario