2023
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasia
2020
Correlating actual one-year weight loss with predicted weight loss by the MBSAQIP: bariatric surgical risk/benefit calculator
Zhou R, Ying L, Valle J, Moore J, Nadzam G, Roberts K, Ghiassi S, Morton J, Duffy A. Correlating actual one-year weight loss with predicted weight loss by the MBSAQIP: bariatric surgical risk/benefit calculator. Surgical Endoscopy 2020, 35: 5705-5708. PMID: 32968922, DOI: 10.1007/s00464-020-08030-4.Peer-Reviewed Original ResearchMeSH KeywordsBariatric SurgeryBody Mass IndexHumansObesityObesity, MorbidRetrospective StudiesRisk AssessmentTreatment OutcomeWeight LossConceptsHigher preoperative BMIBariatric surgeryWeight lossActual weight lossPreoperative BMIOne-year weight lossYale-New Haven HospitalNational databasePatient preoperative informationMethodsA retrospective reviewBody mass indexBackgroundThe American SocietyNew Haven HospitalUnpaired t-testObese patientsPatient factorsRetrospective reviewMass indexPreoperative discussionPreoperative informationBMI pointsBMIPatientsInformed consentSurgery