2023
A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation
Monte A, Vest A, Reisz J, Berninzoni D, Hart C, Dylla L, D’Alessandro A, Heard K, Wood C, Pattee J. A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation. Journal Of Medical Toxicology 2023, 19: 255-261. PMID: 37231244, PMCID: PMC10212224, DOI: 10.1007/s13181-023-00951-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAlanine TransaminaseChemical and Drug Induced Liver InjuryGenome-Wide Association StudyHumansMaltoseMultiomicsUreaConceptsGenome-wide association studiesTricarboxylic acid cycleMitochondrial energy productionLiver injuryGenomic dataALT elevationIdentification of genesTherapeutic doses of APAPAlanine aminotransferase elevationPredicting liver injuryDose of APAPMaltose metabolismAPAP-induced liver injuryMechanism of injuryAssociation studiesGenetic analysisRandomized controlled trialsAminotransferase elevationGenetic variantsAcid cycleClinical outcomesTherapeutic dosesMultiomics approachGenetic controlAPAP liver injury
2022
Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences
Arnold C, Dylla L, Monte A, Heard K, Heard S, D’Alessandro A, Reynolds K, Dart R, Rumack B, Sonn B. Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences. Journal Of Medical Toxicology 2022, 18: 297-310. PMID: 35751009, PMCID: PMC9492831, DOI: 10.1007/s13181-022-00903-5.Peer-Reviewed Original ResearchConceptsTherapeutic APAP dosingAdduct formationN-acetyl-p-benzoquinone imineFalse discovery rate correctionAPAP doseProtein adduct formationAdduction groupLiquid chromatography mass spectrometryUltra-high performance liquid chromatography mass spectrometryMetabolite expressionN-acetyl-p-benzoquinoneAlanine aminotransferaseChromatography mass spectrometrySeverity of hepatic injuryMethodsThis retrospective studyProtein adductsMass spectrometryAdductsAdduct productionAPAP-protein adductsT-testTransaminase elevationMetabolomics evaluationIndependent of sexRetrospective study