2024
Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts
Li Y, Saba L, Scheinman R, Banda N, Holers M, Monte A, Dylla L, Moghimi S, Simberg D. Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts. ACS Nano 2024, 18: 28649-28658. PMID: 39395006, DOI: 10.1021/acsnano.4c05087.Peer-Reviewed Original ResearchConceptsPegylated liposomal doxorubicinComplement activationPredictive valuePlasma concentrationsC-reactive protein levelsAnti-PEG IgGTriggers proinflammatory responsesAnti-PEG IgMEfficacy of nanomedicinesPoor predictive valueAnti-PEG antibodiesLiposomal doxorubicinIron oxide nanowormsHealthy donorsHigher complement activationAcute infectionInflammatory disease conditionsChronic inflammationProinflammatory responseSystemic administrationComplement cascadeComplement factorsComplement responseIgMProtein levelsOptimized Enzyme-Linked Immunosorbent Assay for Anti-PEG Antibody Detection in Healthy Donors and Patients Treated with PEGylated Liposomal Doxorubicin
Li Y, Ettah U, Jacques S, Gaikwad H, Monte A, Dylla L, Guntupalli S, Moghimi S, Simberg D. Optimized Enzyme-Linked Immunosorbent Assay for Anti-PEG Antibody Detection in Healthy Donors and Patients Treated with PEGylated Liposomal Doxorubicin. Molecular Pharmaceutics 2024, 21: 3053-3060. PMID: 38743264, DOI: 10.1021/acs.molpharmaceut.4c00278.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayLiposomal doxorubicinHealthy donorsPatients treated with pegylated liposomal doxorubicinEnzyme-linked immunosorbent assay signalCancer patientsAnti-PEG IgGPegylated liposomal doxorubicinImmunosorbent assayOptimized ELISAEnzyme-linked immunosorbent assay protocolsAnti-PEG antibodiesChemotherapy cyclesBetween-assay variabilityPEGylated liposomesCutoff valueAccelerated clearanceTreatment cyclesDrug delivery systemsAntibody titersComplement activationInfused drugAnti-PEGOptimized assayPatients
2023
Hyperoxia is associated with a greater risk for mortality in critically ill traumatic brain injury patients than in critically ill trauma patients without brain injury
Douin D, Dylla L, Anderson E, Rice J, Jackson C, Bebarta V, Neumann R, Schauer S, Ginde A. Hyperoxia is associated with a greater risk for mortality in critically ill traumatic brain injury patients than in critically ill trauma patients without brain injury. Science Progress 2023, 106: 00368504231160416. PMID: 36879502, PMCID: PMC10450323, DOI: 10.1177/00368504231160416.Peer-Reviewed Original ResearchConceptsTraumatic brain injury statusTraumatic brain injuryIntensive care unitTraumatic brain injury patientsIn-hospital mortalityCritically ill trauma patientsTrauma patientsState Trauma RegistryNon-TBI patientsRisk of mortalityIntensive care unit daysCritically ill TBI patientsRegional trauma centerRetrospective cohort studyIntensive care unit length of stayLength of stayBrain injuryIntensive care unit lengthTrauma registryInjured adultsSecondary analysisBrain injury patientsCohort studyPatient observationSecondary outcomes
2022
Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences
Arnold C, Dylla L, Monte A, Heard K, Heard S, D’Alessandro A, Reynolds K, Dart R, Rumack B, Sonn B. Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences. Journal Of Medical Toxicology 2022, 18: 297-310. PMID: 35751009, PMCID: PMC9492831, DOI: 10.1007/s13181-022-00903-5.Peer-Reviewed Original ResearchConceptsTherapeutic APAP dosingAdduct formationN-acetyl-p-benzoquinone imineFalse discovery rate correctionAPAP doseProtein adduct formationAdduction groupLiquid chromatography mass spectrometryUltra-high performance liquid chromatography mass spectrometryMetabolite expressionN-acetyl-p-benzoquinoneAlanine aminotransferaseChromatography mass spectrometrySeverity of hepatic injuryMethodsThis retrospective studyProtein adductsMass spectrometryAdductsAdduct productionAPAP-protein adductsT-testTransaminase elevationMetabolomics evaluationIndependent of sexRetrospective study
2021
Association Between Chronic Inflammatory Diseases and Stroke-Associated Pneumonia – An Epidemiological Study
Dylla L, Herson P, Poisson S, Rice J, Ginde A. Association Between Chronic Inflammatory Diseases and Stroke-Associated Pneumonia – An Epidemiological Study. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 105605. PMID: 33482567, PMCID: PMC7946738, DOI: 10.1016/j.jstrokecerebrovasdis.2021.105605.Peer-Reviewed Original ResearchConceptsAssociated with reduced in-hospital mortalityRisk of stroke-associated pneumoniaIn-hospital mortalityStroke-associated pneumoniaIn-hospital stroke-associated pneumoniaAssociated with increased risk of strokePost-acute ischemic strokeAssociated with increased riskMultivariate logistic regressionNational Inpatient SampleAssociated with reduced ratesRisk of strokeStroke morbidityRheumatoid arthritisDecreased riskHospital dischargeInpatient SampleLogistic regressionEpidemiological studiesChronic inflammatory diseaseStrokeIschemic strokeMultiple chronic inflammatory diseasesInflammatory bowel diseaseMortality
2018
Dexamethasone-Related Perineal Burning in the Prehospital Setting: A Case Series
Dylla L, Acquisto N, Manzo F, Cushman J. Dexamethasone-Related Perineal Burning in the Prehospital Setting: A Case Series. Prehospital Emergency Care 2018, 22: 655-658. PMID: 29485338, DOI: 10.1080/10903127.2018.1440039.Peer-Reviewed Original Research
2017
Along the Colorado Trail: Assessing the average hikers' knowledge of altitude sickness
Dylla L, Saulle M, Daingerfield E, Jones C, Bodkin R. Along the Colorado Trail: Assessing the average hikers' knowledge of altitude sickness. The American Journal Of Emergency Medicine 2017, 36: 1108-1109. PMID: 29033345, DOI: 10.1016/j.ajem.2017.10.011.Peer-Reviewed Original ResearchAssessing adherence with preventive screening recommendations among ED patients: Piloting an effective use of wait time
Abar B, Dylla L, Sergeant M, Pasternack J, Adler D. Assessing adherence with preventive screening recommendations among ED patients: Piloting an effective use of wait time. The American Journal Of Emergency Medicine 2017, 36: 1105-1106. PMID: 28978401, DOI: 10.1016/j.ajem.2017.09.053.Peer-Reviewed Original Research