A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial
Dylla L, Douin D, Anderson E, Rice J, Jackson C, Bebarta V, Lindsell C, Cheng A, Schauer S, Ginde A. A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial. Trials 2021, 22: 784. PMID: 34749762, PMCID: PMC8574946, DOI: 10.1186/s13063-021-05688-6.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsImplementation trialStatistical analysis planMultimodal interventionTrauma patientsTraining periodStudy protocolTargeted normoxiaVentilator-free daysOne-month training periodGlasgow Outcome ScoreAnalysis planLevel 1 trauma centerCombat casualty careUsual carePre-implementationInjured trauma patientsSupplemental oxygenPost-implementationReduced logistical burdensIntervention phaseOutcome measuresCasualty careMulticenter clusterOutcome scoresAssociation Between Hyperoxia, Supplemental Oxygen, and Mortality in Critically Injured Patients
Douin D, Anderson E, Dylla L, Rice J, Jackson C, Wright F, Bebarta V, Schauer S, Ginde A. Association Between Hyperoxia, Supplemental Oxygen, and Mortality in Critically Injured Patients. Critical Care Explorations 2021, 3: e0418. PMID: 34036272, PMCID: PMC8133168, DOI: 10.1097/cce.0000000000000418.Peer-Reviewed Original ResearchIn-hospital mortalityAdult trauma patientsInjured patientsCohort studyRisk scoreTrauma patientsEmergency department arrivalLevel I trauma centerOutcome of in-hospital mortalityICU admissionMechanism of injuryRisk of mortalityRetrospective cohort studyBlunt trauma mechanismHigh oxygen administrationOxygen administrationSecondary outcomesPrimary outcomeOxygen saturationLevel IIIVentilator-free daysHospital-free daysDays of hospitalizationCritically ill patientsPeriod of hyperoxia