A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial
Dylla L, Douin D, Anderson E, Rice J, Jackson C, Bebarta V, Lindsell C, Cheng A, Schauer S, Ginde A. A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial. Trials 2021, 22: 784. PMID: 34749762, PMCID: PMC8574946, DOI: 10.1186/s13063-021-05688-6.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsImplementation trialStatistical analysis planMultimodal interventionTrauma patientsTraining periodStudy protocolTargeted normoxiaVentilator-free daysOne-month training periodGlasgow Outcome ScoreAnalysis planLevel 1 trauma centerCombat casualty careUsual carePre-implementationInjured trauma patientsSupplemental oxygenPost-implementationReduced logistical burdensIntervention phaseOutcome measuresCasualty careMulticenter clusterOutcome scoresA quasiexperimental study of targeted normoxia in critically ill trauma patients
Dylla L, Anderson E, Douin D, Jackson C, Rice J, Schauer S, Neumann R, Bebarta V, Wright F, Ginde A. A quasiexperimental study of targeted normoxia in critically ill trauma patients. Journal Of Trauma And Acute Care Surgery 2021, 91: s169-s175. PMID: 33797494, PMCID: PMC9709909, DOI: 10.1097/ta.0000000000003177.Peer-Reviewed Original ResearchConceptsCritically ill trauma patientsPostintervention subjectsPostintervention periodTrauma patientsTargeted normoxiaIntervention increased adherenceSupplemental oxygenChronic Health Evaluation II scoreEmergency department arrivalNeurosurgical intensive care unitMilitary trauma patientsIntensive care unitCOnsensus-basedQuasiexperimental studyPostinterventionLevels of FiO2Acute PhysiologyPatient timeII scoreClinical outcomesMm HgTherapeutic/care managementAvoidance of hypoxiaReduce morbidityPrimary outcome