2024
Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke
Dylla L, Higgins H, Poisson S, Vu T, Reisz J, Herson P, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clinical Therapeutics 2024 PMID: 39603869, DOI: 10.1016/j.clinthera.2024.10.015.Peer-Reviewed Original ResearchAcute ischemic strokeQuinolinic acid levelsLevels of tryptophanNIHSS scoreTryptophan metabolismMetabolite levelsKynurenine pathwayLinear regression modelsIncreased lifetime risk of strokeLifetime risk of strokeMass spectrometry-based metabolomicsPotential sex differencesDownstream kynurenine metabolitesAssociated with poor outcomesIschemic strokeKynurenine pathway metabolitesDecreased tryptophan concentrationsIncreased lifetime riskRegression modelsMultivariate linear regression modelSex differencesExperience worse outcomesRisk of strokeAcid levelsKynurenine metabolites
2022
Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes—Where is the data: A systematic review
Dylla L, Higgins H, Piper C, Poisson S, Herson P, Monte A. Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes—Where is the data: A systematic review. Frontiers In Neurology 2022, 13: 1026431. PMID: 36504643, PMCID: PMC9729945, DOI: 10.3389/fneur.2022.1026431.Peer-Reviewed Original ResearchResponse to acute ischemic strokeAcute ischemic strokeIschemic strokeSystematic reviewNeurological outcomePathophysiology of acute ischemic strokePreclinical rat modelClinical cohort studyFull-text reviewNational Institutes of Health (NIHWeb of ScienceAcute stroke researchClinical research studiesSubgroup analysisCohort studyRat modelBiological variablesResearch studiesSex differencesSex-based differencesOvid MEDLINEStudy designLifetime morbidityMetabolic changesPatient outcomes