2024
Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke
Dylla L, Higgins H, Stephenson D, Reisz J, Vu T, Poisson S, Herson P, Monte A. Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke. Journal Of Women's Health 2024, 33: 1378-1384. PMID: 38946610, PMCID: PMC11564668, DOI: 10.1089/jwh.2023.1133.Peer-Reviewed Original ResearchIschemic strokeLinear regression modelsMass spectrometry-based metabolomicsLifetime risk of strokeAssociated with neurological outcomeDifferentially expressed metabolitesRegression modelsAcute ischemic strokeRisk of strokeComprehensive stroke centerBlood metabolomeNeurological outcomeAcute treatmentMetabolomic profilesLifetime riskNeurological functionIndividual metabolitesTherapeutic potentialStroke centersAcute responseResults:</i></b>Study objectiveMetabolomicsStrokeNIHSS
2022
Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes—Where is the data: A systematic review
Dylla L, Higgins H, Piper C, Poisson S, Herson P, Monte A. Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes—Where is the data: A systematic review. Frontiers In Neurology 2022, 13: 1026431. PMID: 36504643, PMCID: PMC9729945, DOI: 10.3389/fneur.2022.1026431.Peer-Reviewed Original ResearchResponse to acute ischemic strokeAcute ischemic strokeIschemic strokeSystematic reviewNeurological outcomePathophysiology of acute ischemic strokePreclinical rat modelClinical cohort studyFull-text reviewNational Institutes of Health (NIHWeb of ScienceAcute stroke researchClinical research studiesSubgroup analysisCohort studyRat modelBiological variablesResearch studiesSex differencesSex-based differencesOvid MEDLINEStudy designLifetime morbidityMetabolic changesPatient outcomes
2019
Prehospital supplemental oxygen for acute stroke – A retrospective analysis
Dylla L, Adler D, Abar B, Benesch C, Jones C, O'Banion M, Cushman J. Prehospital supplemental oxygen for acute stroke – A retrospective analysis. The American Journal Of Emergency Medicine 2019, 38: 2324-2328. PMID: 31787444, PMCID: PMC7231670, DOI: 10.1016/j.ajem.2019.11.002.Peer-Reviewed Original ResearchConceptsRespiratory complicationsNeurological outcomeSupplemental oxygenRetrospective analysisRate of respiratory complicationsPrehospital oxygen saturationAdministration of supplemental oxygenAssociated with neurological outcomeMultivariate logistic regressionAcademic comprehensive stroke centerSubjects' medical records.Comprehensive stroke centerClinical characteristicsRespiratory compromiseAcute stroke patientsRetrospective natureEligible patientsNo significant increaseImprove stroke outcomesMedical recordsGuidelines-Stroke registryOxygen saturationPenumbral tissuePotential confoundersControl):