2024
Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke
Dylla L, Higgins H, Poisson S, Vu T, Reisz J, Herson P, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clinical Therapeutics 2024 PMID: 39603869, DOI: 10.1016/j.clinthera.2024.10.015.Peer-Reviewed Original ResearchAcute ischemic strokeQuinolinic acid levelsLevels of tryptophanNIHSS scoreTryptophan metabolismMetabolite levelsKynurenine pathwayLinear regression modelsIncreased lifetime risk of strokeLifetime risk of strokeMass spectrometry-based metabolomicsPotential sex differencesDownstream kynurenine metabolitesAssociated with poor outcomesIschemic strokeKynurenine pathway metabolitesDecreased tryptophan concentrationsIncreased lifetime riskRegression modelsMultivariate linear regression modelSex differencesExperience worse outcomesRisk of strokeAcid levelsKynurenine metabolitesIdentification of specific recommendations for prehospital stroke care associated with shorter door-to-CT times – An analysis of Get with the Guidelines-Stroke registry and prehospital data
Dylla L, Higgins H, Wham C, Leppert M, Ravare B, Jeppson K, Bina H, Monte A, Poisson S. Identification of specific recommendations for prehospital stroke care associated with shorter door-to-CT times – An analysis of Get with the Guidelines-Stroke registry and prehospital data. Frontiers In Stroke 2024, 3: 1355889. DOI: 10.3389/fstro.2024.1355889.Peer-Reviewed Original ResearchDoor-to-CT timeAmerican Heart AssociationGuidelines-Stroke registryAmerican Heart Association recommendationsPrehospital careStroke patientsEmergency medical services documentationIschemic stroke patientsDoor-to-computed tomographyCare of stroke patientsPrehospital medical recordsPrehospital Stroke ScaleCare of strokeMultivariate linear regression modelPrehospital providersPrehospital dataProvider educationStroke signsPotential confoundersLinear regression modelsTreatment of acute strokeComprehensive stroke centerDescriptive statisticsSuspected strokeMedical records
2023
Abstract TP47: Impact Of Prehospital Care And Patient Presentation On In-hospital Treatment Of Acute Ischemic Stroke
DYLLA L, Higgins H, Ravare B, Jeppson K, Bina H, Rice J, Herson P, Monte A, Poisson S. Abstract TP47: Impact Of Prehospital Care And Patient Presentation On In-hospital Treatment Of Acute Ischemic Stroke. Stroke 2023, 54: atp47-atp47. DOI: 10.1161/str.54.suppl_1.tp47.Peer-Reviewed Original ResearchEmergency medicine servicesDoor-to-CT timeAmerican Heart AssociationLinear regression modelsDoor-to-computed tomographyIn-hospital quality of careQuality-of-care metricsGuideline concordant careQuality of careAcute stroke careDoor-to-CTIn-hospital careRegression modelsMultivariate linear regression modelConcordant careProvider compliancePrehospital careStroke careStroke guidelinesIschemic stroke patientsMedicine serviceStroke symptomsIn-hospital outcomesComprehensive stroke centerAcute ischemic stroke patients