2023
A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation
Monte A, Vest A, Reisz J, Berninzoni D, Hart C, Dylla L, D’Alessandro A, Heard K, Wood C, Pattee J. A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation. Journal Of Medical Toxicology 2023, 19: 255-261. PMID: 37231244, PMCID: PMC10212224, DOI: 10.1007/s13181-023-00951-5.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTricarboxylic acid cycleMitochondrial energy productionLiver injuryGenomic dataALT elevationIdentification of genesTherapeutic doses of APAPAlanine aminotransferase elevationPredicting liver injuryDose of APAPMaltose metabolismAPAP-induced liver injuryMechanism of injuryAssociation studiesGenetic analysisRandomized controlled trialsAminotransferase elevationGenetic variantsAcid cycleClinical outcomesTherapeutic dosesMultiomics approachGenetic controlAPAP liver injury
2021
Association Between Hyperoxia, Supplemental Oxygen, and Mortality in Critically Injured Patients
Douin D, Anderson E, Dylla L, Rice J, Jackson C, Wright F, Bebarta V, Schauer S, Ginde A. Association Between Hyperoxia, Supplemental Oxygen, and Mortality in Critically Injured Patients. Critical Care Explorations 2021, 3: e0418. PMID: 34036272, PMCID: PMC8133168, DOI: 10.1097/cce.0000000000000418.Peer-Reviewed Original ResearchIn-hospital mortalityAdult trauma patientsInjured patientsCohort studyRisk scoreTrauma patientsEmergency department arrivalLevel I trauma centerOutcome of in-hospital mortalityICU admissionMechanism of injuryRisk of mortalityRetrospective cohort studyBlunt trauma mechanismHigh oxygen administrationOxygen administrationSecondary outcomesPrimary outcomeOxygen saturationLevel IIIVentilator-free daysHospital-free daysDays of hospitalizationCritically ill patientsPeriod of hyperoxia