Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke
Dylla L, Higgins H, Poisson S, Vu T, Reisz J, Herson P, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clinical Therapeutics 2024 PMID: 39603869, DOI: 10.1016/j.clinthera.2024.10.015.Peer-Reviewed Original ResearchAcute ischemic strokeQuinolinic acid levelsLevels of tryptophanNIHSS scoreTryptophan metabolismMetabolite levelsKynurenine pathwayLinear regression modelsIncreased lifetime risk of strokeLifetime risk of strokeMass spectrometry-based metabolomicsPotential sex differencesDownstream kynurenine metabolitesAssociated with poor outcomesIschemic strokeKynurenine pathway metabolitesDecreased tryptophan concentrationsIncreased lifetime riskRegression modelsMultivariate linear regression modelSex differencesExperience worse outcomesRisk of strokeAcid levelsKynurenine metabolitesSex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke
Dylla L, Higgins H, Stephenson D, Reisz J, Vu T, Poisson S, Herson P, Monte A. Sex Differences in the Blood Metabolome During Acute Response to Ischemic Stroke. Journal Of Women's Health 2024, 33: 1378-1384. PMID: 38946610, PMCID: PMC11564668, DOI: 10.1089/jwh.2023.1133.Peer-Reviewed Original ResearchIschemic strokeLinear regression modelsMass spectrometry-based metabolomicsLifetime risk of strokeAssociated with neurological outcomeDifferentially expressed metabolitesRegression modelsAcute ischemic strokeRisk of strokeComprehensive stroke centerBlood metabolomeNeurological outcomeAcute treatmentMetabolomic profilesLifetime riskNeurological functionIndividual metabolitesTherapeutic potentialStroke centersAcute responseResults:</i></b>Study objectiveMetabolomicsStrokeNIHSS