A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation
Monte A, Vest A, Reisz J, Berninzoni D, Hart C, Dylla L, D’Alessandro A, Heard K, Wood C, Pattee J. A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation. Journal Of Medical Toxicology 2023, 19: 255-261. PMID: 37231244, PMCID: PMC10212224, DOI: 10.1007/s13181-023-00951-5.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTricarboxylic acid cycleMitochondrial energy productionLiver injuryGenomic dataALT elevationIdentification of genesTherapeutic doses of APAPAlanine aminotransferase elevationPredicting liver injuryDose of APAPMaltose metabolismAPAP-induced liver injuryMechanism of injuryAssociation studiesGenetic analysisRandomized controlled trialsAminotransferase elevationGenetic variantsAcid cycleClinical outcomesTherapeutic dosesMultiomics approachGenetic controlAPAP liver injury