2000
NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat
Mackler S, Korutla L, Cha X, Koebbe M, Fournier K, Bowers M, Kalivas P. NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat. Journal Of Neuroscience 2000, 20: 6210-6217. PMID: 10934270, PMCID: PMC6772573, DOI: 10.1523/jneurosci.20-16-06210.2000.Peer-Reviewed Original ResearchConceptsPOZ/BTB proteinBTB proteinsTranscriptional regulatorsNAC-1POZ/BTB domainZinc finger regionTwo-hybrid studiesDNA-binding proteinsBTB domainTranscription factorsGene transcriptionFinger regionReporter geneProteinNuclei of neuronsMammalian brainTranscriptionBehavioral sensitizationPox virusRegulatorCell culturesAdministration of cocaineRat nucleus accumbensExpressionLong-term neuroadaptations
1999
SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes
Korutla L, Strayer D. SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes. Journal Of Cellular Physiology 1999, 178: 379-386. PMID: 9989784, DOI: 10.1002/(sici)1097-4652(199903)178:3<379::aid-jcp12>3.0.co;2-c.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCarrier ProteinsCells, CulturedFemaleGene Expression RegulationGenes, fosGenes, junMacrophages, PeritonealProteolipidsPulmonary AlveoliPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsType II cellsSurfactant secretionProtein gene transcriptionSurfactant proteinsSurfactant gene expressionOverall transcript levelsC-fos transcriptionSP-A receptorII cellsSP-C mRNA levelsHost antimicrobial defenseSurfactant proteins SPMRNA levelsTranscript stabilityGene transcriptionSP-A effectsTranscript levelsGene expressionTranscriptionC-JunAlveolar type II cellsNew transcriptionSurfactant-associated proteinsSpProtein
1997
Surfactant protein-A receptor-mediated inhibition of calcium signaling in alveolar type II cells.
Strayer D, Korutla L, Thomas A. Surfactant protein-A receptor-mediated inhibition of calcium signaling in alveolar type II cells. Receptors & Signal Transduction 1997, 7: 111-20. PMID: 9392439.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBiological TransportCalciumIonomycinMalePhospholipidsProteolipidsPulmonary AlveoliPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRats, Sprague-DawleyReceptors, Cell SurfaceSignal TransductionThapsigarginConceptsReceptor-mediated inhibitionType II cellsII cellsSP-A receptorSurfactant proteinsType II alveolar cellsReceptor-mediated mechanismAlveolar type II cellsCell membrane receptorsQuantitative fluorescence microscopyAbsence of SPMembrane Ca channelsAction of SPFura-2Membrane receptorsCa storesBiphasic increaseIntracellular storesAlveolar cellsElicit Ca2Physiologic regulatorCalcium ionophoreCa channelsCell membraneIntracellular Ca
1994
Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat
Korutla L, Stewart G, Lasz E, Maione T, Niewiarowski S. Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat. Thrombosis And Haemostasis 1994, 71: 609-614. PMID: 8091389, DOI: 10.1055/s-0038-1642491.Peer-Reviewed Original ResearchConceptsRecombinant platelet factor 4Platelet factor 4Protamine sulfatePartial thromboplastin timeFactor 4Heparin clearanceHeparin neutralizationThromboplastin timeVitro additionClearance studiesDifferent physiological effectsAdverse effectsRatsOrgan depositionHeparinAnticoagulant activityPhysiological effectsGreater percentageLoss of radioactivityHalf lifeHeparin-agarose chromatographyInjectionMinLarge percentageRadioactivity