2000
Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder
Bremner J, Innis R, Southwick S, Staib L, Zoghbi S, Charney D. Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder. American Journal Of Psychiatry 2000, 157: 1120-1126. PMID: 10873921, DOI: 10.1176/appi.ajp.157.7.1120.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingPosttraumatic stress disorderBenzodiazepine receptorsReceptor bindingPrefrontal cortexComparison subjectsCase-matched healthy comparison subjectsDistribution volumeStress disorderSymptoms of PTSDBenzodiazepine receptor functionLow distribution volumeHealthy comparison subjectsCombat-related posttraumatic stress disorderMedial prefrontal cortexCentral benzodiazepine receptorsSingle photon emissionStatistical parametric mappingFrontal cortexPTSD patientsPatientsReceptor functionCortexTomography imagingParametric mappingSPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder
Bremner J, Innis R, White T, Fujita M, Silbersweig D, Goddard A, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney D. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 2000, 47: 96-106. PMID: 10664825, DOI: 10.1016/s0006-3223(99)00188-2.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingBenzodiazepine receptor functionPanic disorder patientsBenzodiazepine receptorsPanic disorderReceptor bindingDisorder patientsPanic attacksReceptor functionPrefrontal cortexSingle photon emissionStatistical parametric mappingGABAergic transmissionHealthy controlsFrontal cortexLeft hippocampusAnimal modelsComparison subjectsPatientsChronic stressPanic anxietyTomography imagingParametric mappingCortexSpecific decrease
1999
Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects
Bremner J, Horti A, Staib L, Zea‐Ponce Y, Soufer R, Charney D, Baldwin R. Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects. Synapse 1999, 35: 68-77. PMID: 10579810, DOI: 10.1002/(sici)1098-2396(200001)35:1<68::aid-syn9>3.0.co;2-h.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainCarbon RadioisotopesFlumazenilHumansKineticsMaleRadioligand AssayReceptors, GABA-ATomography, Emission-ComputedConceptsBenzodiazepine receptor bindingHealthy human subjectsReceptor bindingBenzodiazepine receptorsHuman subjectsBenzodiazepine receptor antagonistCompartment modelReceptor antagonistMultiple time pointsBolus injectionArterial samplesTime-activity curvesSPECT radioligandBrain tissueBrain tissue compartmentsPET imagingTime pointsPrior reportsRadioligandParent compoundTissue compartmentsRadioligand concentrationHigh specific activityWiley-LissReceptorsQuantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects
Bremner J, Baldwin R, Horti A, Staib L, Ng C, Tan P, Zea-Ponce Y, Zoghbi S, Seibyl J, Soufer R, Charney D, Innis R. Quantitation of benzodiazepine receptor binding with PET [11C]iomazenil and SPECT [123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Research 1999, 91: 79-91. PMID: 10515463, DOI: 10.1016/s0925-4927(99)00015-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBenzodiazepine receptorsArterial blood samplesBenzodiazepine receptor bindingHealthy human subjectsHuman subjectsNeuroreceptor bindingSingle photon emissionSingle bolusOccipital cortexBlood samplesTemporal cortexEmission tomographyBrain compartmentsDynamic positron emission tomographyReceptor bindingSPECTSame human subjectsPhoton emissionCortexHuman brainRadioligandPreliminary findingsBrainReceptors