Reduced volume of orbitofrontal cortex in major depression
Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, Staib LH, Charney DS. Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry 2002, 51: 273-279. PMID: 11958777, DOI: 10.1016/s0006-3223(01)01336-1.Peer-Reviewed Original ResearchConceptsMajor depressionOrbitofrontal cortexOrbitofrontal cortical volumeCortical volumeArea 32Area 24Brodmann's area 32Recent postmortem studiesWhole brain volumeSymptoms of depressionBrodmann's area 24Magnetic resonance imagingFrontal cortical regionsFunctional neuroimaging studiesSubcallosal gyrusDepressed patientsPostmortem studiesCortical subregionsComparison subjectsBrain volumePatientsResonance imagingCortical regionsCortexNeuroimaging studies