2000
Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder
Bremner J, Innis R, Southwick S, Staib L, Zoghbi S, Charney D. Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder. American Journal Of Psychiatry 2000, 157: 1120-1126. PMID: 10873921, DOI: 10.1176/appi.ajp.157.7.1120.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingPosttraumatic stress disorderBenzodiazepine receptorsReceptor bindingPrefrontal cortexComparison subjectsCase-matched healthy comparison subjectsDistribution volumeStress disorderSymptoms of PTSDBenzodiazepine receptor functionLow distribution volumeHealthy comparison subjectsCombat-related posttraumatic stress disorderMedial prefrontal cortexCentral benzodiazepine receptorsSingle photon emissionStatistical parametric mappingFrontal cortexPTSD patientsPatientsReceptor functionCortexTomography imagingParametric mapping
1999
Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study
Bremner J, Staib L, Kaloupek D, Southwick S, Soufer R, Charney D. Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biological Psychiatry 1999, 45: 806-816. PMID: 10202567, PMCID: PMC3233761, DOI: 10.1016/s0006-3223(98)00297-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderNon-PTSD subjectsBlood flowVietnam combat veteransCerebral blood flow responseStress disorderBlood flow responsePositron emission tomography studySymptoms of patientsCerebral blood flowSubcortical brain areasEmission tomography studiesCombat veteransMedial prefrontal cortexPositron emission tomographyInferior parietal cortexNeural correlatesVisuospatial processingPTSD subjectsPTSD patientsBrain areasLingual gyrusAnterior cingulatePosterior cingulateParietal cortex
1997
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report
Bremner J, Randall P, Vermetten E, Staib L, Bronen R, Mazure C, Capelli S, McCarthy G, Innis R, Charney D. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report. Biological Psychiatry 1997, 41: 23-32. PMID: 8988792, PMCID: PMC3229101, DOI: 10.1016/s0006-3223(96)00162-x.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLeft hippocampal volumeHippocampal volumeChildhood abuseAdult survivorsSmaller left hippocampal volumeAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesCombat-related posttraumatic stress disorderMagnetic resonance imagingShort-term memoryHealthy subjectsYears of educationAlcohol abuseMagnetic resonance imaging-based measurementsComparison subjectsPTSD patientsImaging-based measurementsResonance imagingPatientsSexual abusePreliminary reportSurvivorsComparison region