2016
In response: Drug‐resistant epilepsy in adults: outcome trajectories after failure of two medications
Choi H, Hayat MJ, Zhang R, Hirsch LJ, Bazil C, Mendiratta A, Kato K, Javed A, Legge AW, Buchsbaum R, Resor S, Heiman G. In response: Drug‐resistant epilepsy in adults: outcome trajectories after failure of two medications. Epilepsia 2016, 57: 1526-1527. PMID: 27594402, DOI: 10.1111/epi.13487.Peer-Reviewed Original Research
2014
The consequences of refractory epilepsy and its treatment
Laxer KD, Trinka E, Hirsch LJ, Cendes F, Langfitt J, Delanty N, Resnick T, Benbadis SR. The consequences of refractory epilepsy and its treatment. Epilepsy & Behavior 2014, 37: 59-70. PMID: 24980390, DOI: 10.1016/j.yebeh.2014.05.031.Peer-Reviewed Original ResearchConceptsRefractory epilepsyPractical clinical recommendationsNew drug therapiesPersistent seizuresOngoing seizuresSurgical treatmentAntiepileptic drugsUncontrolled seizuresDrug therapyEpilepsy expertsEpileptogenic processPsychosocial burdenClinical recommendationsNeuropsychiatric impairmentNervous systemEpilepsyProgressive epilepsySeizuresDiagnostic proceduresVocational consequencesAdverse effectsPatientsRiskTreatmentBurden
2010
Comparative Effectiveness of 10 Antiepileptic Drugs in Older Adults With Epilepsy
Arif H, Buchsbaum R, Pierro J, Whalen M, Sims J, Resor SR, Bazil CW, Hirsch LJ. Comparative Effectiveness of 10 Antiepileptic Drugs in Older Adults With Epilepsy. JAMA Neurology 2010, 67: 408-415. PMID: 20385905, DOI: 10.1001/archneurol.2010.49.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAminesAnticonvulsantsCarbamazepineCyclohexanecarboxylic AcidsDose-Response Relationship, DrugDrug ResistanceEpilepsyFemaleFructoseGabapentinGamma-Aminobutyric AcidHumansLamotrigineLevetiracetamMaleMiddle AgedOxcarbazepinePhenytoinPiracetamRetrospective StudiesTopiramateTreatment OutcomeTriazinesConceptsSeizure freedom ratesAntiepileptic drugsSeizure freedomOlder adultsOverall groupColumbia Comprehensive Epilepsy CenterAdverse effectsIntolerable adverse effectsFirst antiepileptic drugPercentage of patientsComprehensive Epilepsy CenterEffective antiepileptic drugGastrointestinal symptomsRefractory diseaseMore patientsRetrospective reviewEpilepsy centersMAIN OUTCOMEDose changesPatientsComparative effectivenessMore monthsOxcarbazepineLevetiracetamRetention rate