2020
Misperceptions on the chance of seizure freedom with antiseizure medications after two failed trials
Blond BN, Hirsch LJ, Mattson RH. Misperceptions on the chance of seizure freedom with antiseizure medications after two failed trials. Epilepsia 2020, 61: 1789-1790. PMID: 32640071, DOI: 10.1111/epi.16594.Peer-Reviewed Original Research
2019
Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures
Tolchin B, Baslet G, Suzuki J, Martino S, Blumenfeld H, Hirsch LJ, Altalib H, Dworetzky BA. Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures. Epilepsia 2019, 60: 986-995. PMID: 30980679, DOI: 10.1111/epi.14728.Peer-Reviewed Original ResearchConceptsPsychogenic nonepileptic seizuresQuality of lifeMI participantsPNES frequencyMotivational interviewingControl participantsNonepileptic seizuresQuaternary care medical centerEmergency department visitsEmergency department utilizationSingle neurologistDepartment visitsTreatment adherenceControl armMedical CenterMI armsSeizuresVisitsTrialsAdherenceParticipantsPsychotherapyAdherentArmReferral
2018
Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures
Husain AM, Lee JW, Kolls BJ, Hirsch LJ, Halford JJ, Gupta PK, Minazad Y, Jones JM, LaRoche SM, Herman ST, Swisher CB, Sinha SR, Palade A, Dombrowski KE, Gallentine WB, Hahn CD, Gerard EE, Bhapkar M, Lokhnygina Y, Westover MB, Consortium F. Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures. Annals Of Neurology 2018, 83: 1174-1185. PMID: 29733464, PMCID: PMC6785201, DOI: 10.1002/ana.25249.Peer-Reviewed Original ResearchConceptsTreatment-emergent adverse eventsNonconvulsive seizuresContinuous electroencephalographyConfidence intervalsEmergent adverse eventsAnn NeurolPrimary endpointAdverse eventsAntiseizure drugsIll patientsElectrographic seizuresMean ageTreatment trialsOptimal treatmentRisk ratioRelative riskComparative effectivenessSeizuresFosphenytoinNoninferiorityPatientsTreatmentTrialsEquivalents/Subjects