2019
Effectiveness of Levetiracetam Monotherapy in Pediatric Patients With Epilepsy
Mazur RD, Wang B, Kato B, Buchsbaum B, Bonito B, Choi H, Hirsch L, Detyniecki K. Effectiveness of Levetiracetam Monotherapy in Pediatric Patients With Epilepsy. Journal Of Child Neurology 2019, 34: 593-597. PMID: 31113283, DOI: 10.1177/0883073819846804.Peer-Reviewed Original ResearchConceptsLevetiracetam monotherapySeizure freedomPediatric patientsTertiary epilepsy centerNumber of patientsCohort of childrenAdverse eventsRetrospective reviewEpilepsy centersEntire cohortProspective studyMean ageMonotherapyPatientsEpilepsyAdverse effectsRetention rateCohortOne-thirdChildrenSeizuresIrritabilityMonths
2018
Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning
Benjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Połczyńska M, Spencer DD, Hirsch LJ. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Human Brain Mapping 2018, 39: 2777-2785. PMID: 29528160, PMCID: PMC6033659, DOI: 10.1002/hbm.24039.Peer-Reviewed Original ResearchConceptsLanguage functional MRISurgical marginsFunctional MRIPatient outcomesClinical practiceEpilepsy surgical planningEpilepsy surgical programsCurrent clinical practiceDirect brain stimulationEpilepsy surgeryStimulation mappingBrain stimulationClinical teamLanguage lateralizationSurgical programsSurgical planningLanguage-critical areasFMRI findingsFMRI paradigmUnexpected preservationFurther validationLanguage declineAdultsOutcomesChildren
2015
Consensus Statement on Continuous EEG in Critically Ill Adults and Children, Part II
Herman ST, Abend NS, Bleck TP, Chapman KE, Drislane FW, Emerson RG, Gerard EE, Hahn CD, Husain AM, Kaplan PW, LaRoche SM, Nuwer MR, Quigg M, Riviello JJ, Schmitt SE, Simmons LA, Tsuchida TN, Hirsch LJ. Consensus Statement on Continuous EEG in Critically Ill Adults and Children, Part II. Journal Of Clinical Neurophysiology 2015, 32: 96-108. PMID: 25626777, PMCID: PMC4434600, DOI: 10.1097/wnp.0000000000000165.Peer-Reviewed Original ResearchConceptsIll adultsConsensus panelAmerican Clinical Neurophysiology SocietyContinuous EEGCritically Ill AdultsIntensive care unitNon-physician personnelExpert consensus recommendationsNeurodiagnostic technologistsQuantitative EEG techniquesCare unitPatient selectionPatient populationMental statusConsensus statementConsensus recommendationsInfection controlBrain functionCommon procedureEEGTask ForceAdultsEEG techniquesChildren
2006
Frequency and Predictors of Nonconvulsive Seizures During Continuous Electroencephalographic Monitoring in Critically Ill Children
Jette N, Claassen J, Emerson RG, Hirsch LJ. Frequency and Predictors of Nonconvulsive Seizures During Continuous Electroencephalographic Monitoring in Critically Ill Children. JAMA Neurology 2006, 63: 1750-1755. PMID: 17172615, DOI: 10.1001/archneur.63.12.1750.Peer-Reviewed Original ResearchConceptsContinuous electroencephalographic monitoringPeriodic lateralized epileptiform dischargesNonconvulsive seizuresIll childrenElectroencephalographic monitoringEpileptiform dischargesMultivariate logistic regression analysisMajority of patientsLogistic regression analysisAbsence of reactivityCEEG initiationClinical seizuresStatus epilepticusPrior seizuresSeizuresMultivariate analysisFirst hourChildrenPatientsRegression analysisBackground reactivityHoursPredictorsHours of recordingsEpilepticusPredictors of Lamotrigine‐associated Rash
Hirsch LJ, Weintraub DB, Buchsbaum R, Spencer HT, Straka T, Hager M, Resor SR. Predictors of Lamotrigine‐associated Rash. Epilepsia 2006, 47: 318-322. PMID: 16499755, DOI: 10.1111/j.1528-1167.2006.00423.x.Peer-Reviewed Original ResearchConceptsAntiepileptic drugsRisk factorsColumbia Comprehensive Epilepsy CenterDrug-related rashStevens-Johnson syndromeToxic epidermal necrolysisComprehensive Epilepsy CenterHistory of rashGreatest risk factorEpidermal necrolysisSevere rashEpilepsy centersMedical historyRemote historyRetrospective analysisRashMedication variablesMultivariate analysisPotential predictorsPatientsStrongest predictorPredictorsLTGTitration rateChildren