2024
Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: Outcomes from the Surveillance HeartCare Outcomes Registry
Khush K, Hall S, Kao A, Raval N, Dhingra R, Shah P, Bellumkonda L, Ravichandran A, Van Bakel A, Uriel N, Patel S, Pinney S, DePasquale E, Baran D, Pinney K, Oreschak K, Kobulnik J, Shen L, Teuteberg J. Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: Outcomes from the Surveillance HeartCare Outcomes Registry. The Journal Of Heart And Lung Transplantation 2024, 43: 1409-1421. PMID: 38759766, DOI: 10.1016/j.healun.2024.05.003.Peer-Reviewed Original ResearchAcute cellular rejectionIncidence of acute cellular rejectionBiopsy rateGene expression profilesNon-invasive testsMolecular testingDd-cfDNACellular rejectionGraft dysfunctionHeart transplantationFollow-up testing ratesIncidence of graft dysfunctionLow biopsy rateFollow-up biopsiesPositive likelihood ratioNon-invasive surveillanceBiopsy dataClinical decision-makingExcellent survivalOutcomes RegistryFollow-upLow incidenceBiopsyPositive groupDual testing
2023
Impact of Steroid Withdrawal on Gene Expression Profiling, Donor Derived Cell-Free DNA, and Clinical Outcomes in the SHORE Registry
Bellumkonda L, Uriel N, Fu Y, Shen L, Qu K, Baran D. Impact of Steroid Withdrawal on Gene Expression Profiling, Donor Derived Cell-Free DNA, and Clinical Outcomes in the SHORE Registry. The Journal Of Heart And Lung Transplantation 2023, 42: s494. DOI: 10.1016/j.healun.2023.02.1362.Peer-Reviewed Original ResearchDe novo donor-specific antibodiesDd-cfDNA levelsCardiac allograft vasculopathySteroid withdrawalGraft dysfunctionCell-free DNAGEP scoreGene expression profilingMulti-organ transplant recipientsNovo donor-specific antibodiesDe novo DSAPost-heart transplantSteroid withdrawal groupDonor-specific antibodiesAllograft vasculopathySteroid doseCause mortalityTransplant recipientsMethods PatientsSteroid treatmentComplete discontinuationPropensity matchingClinical outcomesOutcomes RegistryWithdrawal group