Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials.
Perrella A, Geen O, Ahuja M, Scott S, Kaushik R, Ferrante L, Brummel N, Muscedere J, Rochwerg B. Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials. Critical Care Medicine 2024 PMID: 38661459, DOI: 10.1097/ccm.0000000000006315.Peer-Reviewed Original ResearchCritical care interventionsRandomized controlled trialsCare interventionsOlder adultsCluster randomized controlled trialStatistically significant effect modificationSubgroup effectsIll older adultsControlled trialsCritically ill older adultsSystematic review of randomized controlled trialsSignificant effect modificationReview of randomized controlled trialsCritical care randomized controlled trialsCritical care journalsStatistically significant subgroup effectsIndividual patient preferencesSubgroups of ageIntervention effectsMultimorbidityEffect modificationFrailty subgroupsICU interventionsStudy characteristicsGeneral medicine