2016
Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials
Lawson JH, Glickman MH, Ilzecki M, Jakimowicz T, Jaroszynski A, Peden EK, Pilgrim AJ, Prichard HL, Guziewicz M, Przywara S, Szmidt J, Turek J, Witkiewicz W, Zapotoczny N, Zubilewicz T, Niklason LE. Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials. The Lancet 2016, 387: 2026-2034. PMID: 27203778, PMCID: PMC4915925, DOI: 10.1016/s0140-6736(16)00557-2.Peer-Reviewed Original ResearchConceptsHuman acellular vesselEnd-stage renal diseaseAcellular vesselsPrimary patencySecondary patencyRenal diseaseDialysis accessHaemodialysis accessPhase 2 single-arm trialSingle-arm phase 2 trialPolytetrafluoroethylene arteriovenous graftsPhase 2 trialDialysis access graftsSingle-arm trialArms of patientsPrimary endpointChronic haemodialysisAccess graftsUS National InstitutesArteriovenous graftsVenous anastomosisCensoring eventIntimal hyperplasiaPatencyPatients
2011
Readily Available Tissue-Engineered Vascular Grafts
Dahl SL, Kypson AP, Lawson JH, Blum JL, Strader JT, Li Y, Manson RJ, Tente WE, DiBernardo L, Hensley MT, Carter R, Williams TP, Prichard HL, Dey MS, Begelman KG, Niklason LE. Readily Available Tissue-Engineered Vascular Grafts. Science Translational Medicine 2011, 3: 68ra9. PMID: 21289273, DOI: 10.1126/scitranslmed.3001426.Peer-Reviewed Original ResearchConceptsTissue-engineered vascular graftsVascular graftsMechanical propertiesSynthetic graftsAutologous tissueCoronary artery bypassCanine smooth muscle cellsPolyglycolic acid scaffoldsTissue engineeringHuman vascular graftsSmooth muscle cellsSynthetic vascular graftsArtery bypassSuch patientsArteriovenous accessArterial bypassHuman blood vesselsCardiovascular diseaseExcellent patencyBaboon modelIntimal hyperplasiaDog modelCellular materialPatientsGraft
2003
Decellularized native and engineered arterial scaffolds for transplantation.
Dahl S, Koh J, Prabhakar V, Niklason L. Decellularized native and engineered arterial scaffolds for transplantation. Cell Transplantation 2003, 12: 659-66. PMID: 14579934.Peer-Reviewed Original Research