2016
Implantable tissue-engineered blood vessels from human induced pluripotent stem cells
Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Biomaterials 2016, 102: 120-129. PMID: 27336184, PMCID: PMC4939127, DOI: 10.1016/j.biomaterials.2016.06.010.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVascular diseaseBlood vesselsAlpha-smooth muscle actinSmooth muscle myosin heavy chainActive vascular remodelingSmooth muscle cellsMuscle myosin heavy chainTissue-engineered blood vesselsStem cellsAbundant collagenous matrixPluripotent stem cellsInterposition graftAllogeneic graftsVascular remodelingΑ-SMANude ratsMuscle actinMyosin heavy chainClinical useMuscle cellsFunctional vascular smooth muscle cellsPatientsFunctional tissue-engineered blood vesselGraft
2012
Microfluidic artificial “vessels” for dynamic mechanical stimulation of mesenchymal stem cells
Zhou J, Niklason LE. Microfluidic artificial “vessels” for dynamic mechanical stimulation of mesenchymal stem cells. Integrative Biology 2012, 4: 1487-1497. PMID: 23114826, PMCID: PMC3628532, DOI: 10.1039/c2ib00171c.Peer-Reviewed Original ResearchMeSH KeywordsBeta CateninBiomechanical PhenomenaBlood VesselsCell DifferentiationCells, CulturedEquipment DesignHumansMesenchymal Stem CellsMicrofluidic Analytical TechniquesSignal TransductionSmad ProteinsStress, MechanicalSystems BiologyTissue EngineeringTransforming Growth Factor betaWnt Signaling PathwayConceptsVascular tissue engineeringMicrofluidic channelTissue engineeringDynamic mechanical stimulationHydrodynamic actuationDeformable membraneDevice fatigueStem cell mechanobiologyCyclic strainComplex mechanical stimulationMechanical environmentCell mechanobiologyMesenchymal stem cellsPerformance degradationCyclic stimulationStem cellsBiomechanical conditionsCyclic circumferential strainMicrochip platformSignal transduction cascadeMechanical stimulationVascular cell lineagesVersatile platformEngineeringCanonical Wnt/β-catenin