Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems
Zheutlin A, Dennis J, Karlsson Linnér R, Moscati A, Restrepo N, Straub P, Ruderfer D, Castro V, Chen C, Ge T, Huckins L, Charney A, Kirchner H, Stahl E, Chabris C, Davis L, Smoller J. Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia in 106,160 Patients Across Four Health Care Systems. American Journal Of Psychiatry 2019, 176: 846-855. PMID: 31416338, PMCID: PMC6961974, DOI: 10.1176/appi.ajp.2019.18091085.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health CareFemaleGenetic PleiotropyGenetic Predisposition to DiseaseHumansMaleMiddle AgedMultifactorial InheritancePenetranceRisk FactorsSchizophreniaConceptsPolygenic risk scoresHealth care systemCare systemGenetic riskAssociated with schizophreniaPolygenic risk score distributionPhenome-wide association studyMeasures of genetic riskRisk scoreHighest risk decileHealth care settingsElectronic health recordsOdds of schizophreniaAssociated with other phenotypesCare settingsRisk decileHealth recordsHigher oddsHealth consequencesResearch cohortAssociation studiesHealthEarly interventionMeta-analysisPersonality disorder