2023
T65. GENES IN POSTMORTEM BRAIN TISSUE DIFFERENTIALLY EXPRESSED IN CHRONIC PAIN
Collier L, Seah C, Kozik E, Group T, Girgenti M, Huckins L, Johnston K. T65. GENES IN POSTMORTEM BRAIN TISSUE DIFFERENTIALLY EXPRESSED IN CHRONIC PAIN. European Neuropsychopharmacology 2023, 75: s196-s197. DOI: 10.1016/j.euroneuro.2023.08.350.Peer-Reviewed Original ResearchChronic painBackground Chronic painBone cancer painPain-related conditionsVEGF BFalse discovery rate correctionCancer painEndometrial cancerRheumatoid arthritisBrain gene expression datasetsGene expressionPainPsychiatric conditionsLinear regression modelsMultiple testingSpecific cell typesGene expression analysisCell typesRate correctionRegression modelsSurrogate variablesDifferential gene expression analysisDACCMeasured variablesExpression
2020
Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts
Huckins L, Chatzinakos C, Breen M, Hartmann J, Klengel T, da Silva Almeida A, Dobbyn A, Girdhar K, Hoffman G, Klengel C, Logue M, Lori A, Maihofer A, Morrison F, Nguyen H, Park Y, Ruderfer D, Sloofman L, van Rooij S, Consortium P, Baker D, Chen C, Cox N, Duncan L, Geyer M, Glatt S, Im H, Risbrough V, Smoller J, Stein D, Yehuda R, Liberzon I, Koenen K, Jovanovic T, Kellis M, Miller M, Bacanu S, Nievergelt C, Buxbaum J, Sklar P, Ressler K, Stahl E, Daskalakis N. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Reports 2020, 31: 107716. PMID: 32492425, PMCID: PMC7359754, DOI: 10.1016/j.celrep.2020.107716.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCase-Control StudiesCohort StudiesDexamethasoneDown-RegulationGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseHumansLeukocytesMaleMiceMice, Inbred C57BLMilitary PersonnelPrefrontal CortexRepressor ProteinsRibonucleoproteins, Small NuclearRNA InterferenceRNA, Small InterferingStress Disorders, Post-TraumaticConceptsPost-traumatic stress disorderGenetically regulated gene expressionPost-traumatic stress disorder casesDorsolateral prefrontal cortexGene expressionU12 intron splicingPrefrontal cortexStress disorderDeployment stressTranscriptome imputationTissue-specific gene expressionDifferential gene expressionMilitary cohortZNF140U12 intronsGenetic heterogeneityExpression changesFunctional roleExogenous glucocorticoidsPeripheral leukocytesEuropean cohortCortexCohortDisordersExpression