2011
Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom
Sachdev V, Kato G, Gibbs J, Barst R, Machado R, Nouraie M, Hassell K, Little J, Schraufnagel D, Krishnamurti L, Novelli E, Girgis R, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Castro O, Taylor J, Hannoush H, Goldsmith J, Gladwin M, Gordeuk V. Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom. Circulation 2011, 124: 1452-1460. PMID: 21900080, PMCID: PMC3183314, DOI: 10.1161/circulationaha.111.032920.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnemia, Sickle CellChildEchocardiographyExercise TestExercise ToleranceFamilial Primary Pulmonary HypertensionFemaleHomozygoteHumansHypertension, PulmonaryMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProspective StudiesPulmonary ArteryTricuspid Valve InsufficiencyUnited KingdomUnited StatesVentricular Dysfunction, LeftYoung AdultConceptsTricuspid regurgitation velocitySickle cell diseaseSickle cell anemiaVentricular diastolic dysfunctionDiastolic dysfunctionCell diseaseCell anemiaPulmonary hypertensionExercise capacityWalk distanceElevated pulmonary artery systolic pressurePulmonary artery systolic pressureSystolic pulmonary artery pressureHomozygous sickle cell anemiaPulmonary pressure elevationLV diastolic dysfunctionLV filling pressurePoor exercise capacityPulmonary artery pressureElevated pulmonary pressuresLong-term outcomesHomozygous hemoglobin SBlood urea nitrogenArtery pressureEchocardiographic markers
2006
Life threatening parvovirus B19 and herpes simplex virus associated acute myocardial dysfunction in a child with homozygous sickle cell disease
Krishnamurti L, Lanford L, Munoz R. Life threatening parvovirus B19 and herpes simplex virus associated acute myocardial dysfunction in a child with homozygous sickle cell disease. Pediatric Blood & Cancer 2006, 49: 1019-1021. PMID: 16700044, DOI: 10.1002/pbc.20855.Peer-Reviewed Original ResearchConceptsSickle cell diseaseHPV B19Parvovirus B19Cell diseaseHemolytic anemiaTransient red cell aplasiaHomozygous sickle cell diseaseAcute myocardial dysfunctionHPV-B19 infectionAcute chest syndromeAcute splenic sequestrationCorrection of anemiaDiagnosis of myocarditisRed cell aplasiaSelf-limiting conditionHuman parvovirus B19Herpes simplex virusChest syndromeFulminant myocarditisB19 infectionCardiopulmonary failureAplastic crisisBlood transfusionMyocardial dysfunctionSCD patients
2002
Mutations in the VHL gene in sporadic apparently congenital polycythemia
Pastore Y, Jelinek J, Ang S, Guan Y, Liu E, Jedlickova K, Krishnamurti L, Prchal J. Mutations in the VHL gene in sporadic apparently congenital polycythemia. Blood 2002, 101: 1591-1595. PMID: 12393546, DOI: 10.1182/blood-2002-06-1843.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArginineAspartic AcidBase SequenceChildChild, PreschoolDNA Mutational AnalysisErythroid Precursor CellsErythropoietinFemaleHeterozygoteHomozygoteHumansLeucineLigasesMaleMutationPedigreePolycythemiaSequence Analysis, DNATryptophanTumor Suppressor ProteinsTyrosineUbiquitin-Protein LigasesValineVon Hippel-Lindau Tumor Suppressor ProteinConceptsVon Hippel-LindauVHL geneTumor suppressor von Hippel-LindauPolycythemic disordersDownstream target genesVHL mutationsHypoxia-sensing pathwayVHL functionHypoxia-inducible factor-1alphaProteosomal degradationTarget genesErythroid cellsGermline VHL mutationsCongenital polycythemiaChuvash polycythemiaVHL syndromeGenesHIF-1alphaDevelopment of tumorsFactor-1alphaElevated serum Epo levelsMutationsEPO productionAutosomal dominant disorderPathway
1998
Homozygous Hemoglobin Constant Spring with Normal Electrophoresis: A Possible Cause for Under‐Diagnosis
KRISHNAMURTI L, LITTLE J. Homozygous Hemoglobin Constant Spring with Normal Electrophoresis: A Possible Cause for Under‐Diagnosis. Annals Of The New York Academy Of Sciences 1998, 850: 415-419. PMID: 9668571, DOI: 10.1111/j.1749-6632.1998.tb10508.x.Peer-Reviewed Original Research