2022
Associated comorbidities, healthcare utilization & mortality in hospitalized patients with haemophilia in the United States: Contemporary nationally representative estimates
Day J, Takemoto C, Sharathkumar A, Makhani S, Gupta A, Bitner S, Josephson C, Bloch E, Tobian A, Krishnamurti L, Goel R. Associated comorbidities, healthcare utilization & mortality in hospitalized patients with haemophilia in the United States: Contemporary nationally representative estimates. Haemophilia 2022, 28: 532-541. PMID: 35412659, PMCID: PMC9540439, DOI: 10.1111/hae.14557.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleHealthcare utilizationPrevalence of comorbiditiesAge-related comorbiditiesCentral line infectionsInpatient discharge databaseOverall mortality rateCatheter-related infectionsHealthcare utilization patternsMedian hospital chargesICD-10 codesRepresentative estimatesCause admissionsCause hospitalizationAdult PWHAssociated comorbidityCommon comorbiditiesHospitalized patientsMedian ageContemporary cohortHospital burdenHospital chargesDischarge databaseInpatient SampleLine infections
2020
Risk Factors and Cardiovascular Disease (CVD) Related Outcomes in Hospitalized Patients with Hemophilia 10 Year Follow up
Day J, Gupta A, Abro C, Jung K, Krishnamurti L, Takemoto C, Goel R. Risk Factors and Cardiovascular Disease (CVD) Related Outcomes in Hospitalized Patients with Hemophilia 10 Year Follow up. Blood 2020, 136: 30-31. DOI: 10.1182/blood-2020-136486.Peer-Reviewed Original ResearchCVD risk factorsAcute myocardial infarctionAtherosclerotic coronary artery diseaseCVD outcomesCoronary artery diseaseNationwide Inpatient SamplePrevalent risk factorsRisk factorsCardiovascular diseaseHaemophilia populationOrder of frequencyHemophilia AArtery diseaseHeart failureHospitalized patientsHaemophilia patientsMean agePrevalence ratesJohns Hopkins Institutional Review BoardUtilization Project Nationwide Inpatient SampleUnadjusted prevalence ratesCardiovascular risk factorsSignificant riskCrude prevalence rateICD-9 codes
2019
Associated Co-Morbidities, Healthcare Utilization, and Mortality in Hospitalized Children and Adults with Hemophilia in the United States: Updated Nationally Representative Estimates and a Comparative Analysis
Gupta A, Hannan A, Maini R, Bitner S, Stone S, Regmi M, Tobian A, Josephson C, Krishnamurti L, Takemoto C, Goel R. Associated Co-Morbidities, Healthcare Utilization, and Mortality in Hospitalized Children and Adults with Hemophilia in the United States: Updated Nationally Representative Estimates and a Comparative Analysis. Blood 2019, 134: 4711. DOI: 10.1182/blood-2019-123161.Peer-Reviewed Original ResearchCongestive heart failureNationwide Inpatient SampleMedian hospital chargesHepatitis CMedian ageHIV/AIDSHospital dischargeInpatient mortalityHeart failureCommon diagnosisHealthcare utilizationHaemophilia patientsHospital chargesMortality rateHemophilia AUtilization Project Nationwide Inpatient SampleYounger ageCommon discharge diagnosesMost hemophilia patientsNon-bleeding complicationsInpatient mortality rateHepatitis C casesCentral line infectionsCoronary artery diseaseInsurance coverage
2015
Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality
Goel R, Ness P, Takemoto C, Krishnamurti L, King K, Tobian A. Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality. Blood 2015, 125: 1470-1476. PMID: 25588677, PMCID: PMC4342358, DOI: 10.1182/blood-2014-10-605493.Peer-Reviewed Original ResearchConceptsImmune thrombocytopenic purpuraThrombotic thrombocytopenic purpuraAcute myocardial infarctionPlatelet transfusionsArterial thrombosisVenous thrombosisHigher oddsHospital mortalityThrombocytopenic purpuraGender-adjusted odds ratioPlatelet transfusion practicesNationwide Inpatient SampleConsumptive disordersHIT patientsTransfusion practiceInpatient SampleMyocardial infarctionClinical severityOdds ratioTransfusionThrombosisPrimary mediatorMortalityLittle dataPurpura
2010
Burden of In-Hospital Care of Thrombotic Microangiopathies In the United States
Gupta A, Krishnamurti L. Burden of In-Hospital Care of Thrombotic Microangiopathies In the United States. Blood 2010, 116: 2559. DOI: 10.1182/blood.v116.21.2559.2559.Peer-Reviewed Original ResearchNationwide Inpatient SampleThrombotic microangiopathyHealth care utilizationRelated hospital admissionsHealthcare utilizationHospital dischargeHospital admissionCare utilizationHospital chargesTherapeutic plasmapheresisAge groupsFrequent healthcare encountersIn-Hospital CarePayer inpatient databaseClinical Modification codesAverage hospital chargesBurden of careNational dataFirst national dataStratified probability sampleU.S. community hospitalsTotal hospitalizationsFrequent hospitalizationsInpatient DatabaseMean duration
2009
National Healthcare Utilization Trends for Deep Vein Thrombosis in the United States.
Viswanathan P, Goswami U, Krishnamurti L. National Healthcare Utilization Trends for Deep Vein Thrombosis in the United States. Blood 2009, 114: 3183. DOI: 10.1182/blood.v114.22.3183.3183.Peer-Reviewed Original ResearchNationwide Inpatient SampleLow molecular weight heparinPostoperative pulmonary embolismDeep vein thrombosisHealth care utilizationMolecular weight heparinPrimary diagnosisSecondary diagnosisPulmonary embolismVein thrombosisAnnual incidenceCare utilizationWeight heparinDischarge diagnosisHospital utilizationAge 18ICD-9-CM diagnosisLarge-scale prospective studiesCommon primary diagnosisPatients age 18Primary discharge diagnosisPulmonary heart diseaseAcute care hospitalsVariety of diagnosesHealthcare utilization trends