2014
A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle‐cell disease
Creary S, Gladwin M, Byrne M, Hildesheim M, Krishnamurti L. A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle‐cell disease. Pediatric Blood & Cancer 2014, 61: 1068-1073. PMID: 24436121, DOI: 10.1002/pbc.24931.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnemia, Sickle CellAntisickling AgentsCell PhoneChildChild, PreschoolDirectly Observed TherapyDrug Administration ScheduleElectronic MailFeedbackFemaleHealth SurveysHumansHydroxyureaMaleMedication AdherenceMicrocomputersPatient SatisfactionPilot ProjectsReimbursement, IncentiveReminder SystemsRewardText MessagingVideo RecordingYoung AdultConceptsSickle cell diseaseMedian medication possession ratioMean corpuscular volumeHU adherenceHydroxyurea adherencePilot studyHemoglobin F percentageMedication possession ratioParticipant satisfactionPossession ratioSecondary outcomesPediatric patientsPrimary outcomeStudy entryClinical outcomesHU useHU therapyOverall participant satisfactionSingle institutionCell diseaseReminder alertsCorpuscular volumeTherapyAdherenceOverall median
2012
Mobile Directly Observed Therapy: Monitoring and Improving Hydroxyurea Adherence in Pediatric Sickle Cell Patients
Creary S, Gladwin M, Krishnamurti L. Mobile Directly Observed Therapy: Monitoring and Improving Hydroxyurea Adherence in Pediatric Sickle Cell Patients. Blood 2012, 120: 2060. DOI: 10.1182/blood.v120.21.2060.2060.Peer-Reviewed Original ResearchSickle cell diseaseMedication possession ratioPediatric sickle cell diseaseLaboratory markersPediatric sickle cell patientsMorisky Medication Adherence ScaleAcute chest syndromeFrequent pain crisesHemoglobin F percentageHemoglobin SS diseasePrescription refill recordsMedication Adherence ScaleAnti-tuberculosis therapyPoor medication adherenceLarge clinical trialsRed blood cell disordersSelf-reported adherenceSickle cell patientsBlood cell disordersDOT participantsHU adherenceChest syndromePain crisisMedication ingestionPossession ratio