2024
Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT
Katoch D, Nallagatla V, Liang J, Deng Y, Krishnamurti L. Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT. Transplantation And Cellular Therapy 2024, 30: s65. DOI: 10.1016/j.jtct.2023.12.103.Peer-Reviewed Original ResearchHematopoietic cell transplantationOutcomes of hematopoietic cell transplantationSickle cell diseaseSymptomatic SCD patientsAsymptomatic patientsDonor typeSymptomatic patientsPost-HCTSCD patientsHematopoietic cell transplantation comorbidity indexPost-transplant lymphoproliferative disorderMedian follow-up periodComplication of sickle cell diseaseIncidence of aGVHDReduced intensity conditioningSickle cell disease patientsFollow-up periodPropensity-matched modelStandardized mean differenceSecondary malignanciesLymphoproliferative disordersCell transplantationGraft survivalPatient ageAssociated with group classification
2023
Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT
Katoch D, Nallagatla V, Krishnamurti L. Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT. Blood 2023, 142: 3873. DOI: 10.1182/blood-2023-190977.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseComplications of SCDGraft failureOverall survivalAsymptomatic patientsAvascular necrosisSCD patientsDonor typeChronic GVHDCell transplantationCell diseaseOutcomes of HCTPost-transplant lymphoproliferative disorderSubstantial short-term morbidityCommon graft sourceExperienced graft failureHCT comorbidity indexAcute chest syndromeHLA-identical donorShort-term morbidityLong-term sequelaePotential curative optionSubset of patientsOrgan-specific complications