2018
Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload?
Goldwater DS, Dharmarajan K, McEwan BS, Krumholz HM. Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? Journal Of Hospital Medicine 2018, 13 PMID: 29813141, DOI: 10.12788/jhm.2986.Peer-Reviewed Original ResearchMeSH KeywordsAllostasisBiomarkersHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemPatient ReadmissionPituitary-Adrenal SystemPostoperative ComplicationsStress, PsychologicalSyndromeConceptsPosthospital syndromeAllostatic overloadAutonomic nervous systemMultiple organ systemsHospital dischargeInflammatory markersAdverse eventsHospital readmissionAdrenal axisAdverse outcomesPlausible etiologyPathophysiologic consequencesElevated riskNervous systemNarrative reviewOrgan systemsEnhanced vulnerabilityElevated levelsHospital environmentTraditional hospital environmentSyndromeMaladaptive statesOverloadOutcomesPossible mechanism
2016
Outcomes 1 Year After Implantable Cardioverter–Defibrillator Lead Abandonment Versus Explantation for Unused or Malfunctioning Leads
Zeitler EP, Wang Y, Dharmarajan K, Anstrom KJ, Peterson ED, Daubert JP, Curtis JP, Al-Khatib SM. Outcomes 1 Year After Implantable Cardioverter–Defibrillator Lead Abandonment Versus Explantation for Unused or Malfunctioning Leads. Circulation Arrhythmia And Electrophysiology 2016, 9: e003953. PMID: 27406605, PMCID: PMC4973616, DOI: 10.1161/circep.116.003953.Peer-Reviewed Original ResearchConceptsNational Cardiovascular Data Registry ICD RegistryLead explantationUpper extremity thrombosisProcedure-related complicationsImplantable cardioverter-defibrillator leadsOutcomes 1 yearLong-term safetyCardioverter-defibrillator leadsHospital complicationsHospital deathUrgent surgeryPulmonary embolismICD RegistryHospital eventsPostprocedure complicationsMortality riskPatientsICD leadPropensity scoreComplicationsExplantationLead abandonmentMalfunctioning leadsHigh rateComparative acuteCoronary Catheterization and Percutaneous Coronary Intervention in China: 10-Year Results From the China PEACE-Retrospective CathPCI Study
Zheng X, Curtis JP, Hu S, Wang Y, Yang Y, Masoudi FA, Spertus JA, Li X, Li J, Dharmarajan K, Downing NS, Krumholz HM, Jiang L. Coronary Catheterization and Percutaneous Coronary Intervention in China: 10-Year Results From the China PEACE-Retrospective CathPCI Study. JAMA Internal Medicine 2016, 176: 512. PMID: 26974883, PMCID: PMC5459379, DOI: 10.1001/jamainternmed.2016.0166.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngina, UnstableCardiac CatheterizationChinaCoronary Artery DiseaseDrug-Eluting StentsFemaleHospital MortalityHospitals, UrbanHumansLength of StayMaleMedical RecordsMiddle AgedMyocardial InfarctionOdds RatioOutcome Assessment, Health CarePercutaneous Coronary InterventionPostoperative ComplicationsPostoperative HemorrhageQuality of Health CareRetrospective StudiesStentsTime-to-TreatmentConceptsPercutaneous coronary interventionDrug-eluting stentsQuality of careCoronary catheterizationCoronary interventionNonobstructive coronary artery diseasePrimary percutaneous coronary interventionFuture quality improvement initiativesEvidence-based medicationsOutcomes of patientsCoronary artery diseaseClinical observational studyUse of catheterizationQuality improvement initiativesCalendar year 2001Hospital mortalityArtery diseasePatient characteristicsStable patientsTreatment patternsMedian lengthMean agePCI proceduresMedical recordsObservational study
2015
Patients need safer hospitals, every day of the week
Dharmarajan K, Kim N, Krumholz HM. Patients need safer hospitals, every day of the week. The BMJ 2015, 350: h1826. PMID: 25877669, DOI: 10.1136/bmj.h1826.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHospitalizationHumansIatrogenic DiseaseMaleMedical ErrorsPostoperative Complications
2014
Trends in Hospitalizations Among Medicare Survivors of Aortic Valve Replacement in the United States From 1999 to 2010
Murugiah K, Wang Y, Dodson JA, Nuti SV, Dharmarajan K, Ranasinghe I, Cooper Z, Krumholz HM. Trends in Hospitalizations Among Medicare Survivors of Aortic Valve Replacement in the United States From 1999 to 2010. The Annals Of Thoracic Surgery 2014, 99: 509-517. PMID: 25527425, PMCID: PMC4454375, DOI: 10.1016/j.athoracsur.2014.08.045.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic ValveFemaleHeart Valve Prosthesis ImplantationHospitalizationHumansMaleMedicarePostoperative ComplicationsSurvivorsTime FactorsUnited StatesConceptsAortic valve replacementValve replacementHospitalization ratesAnnual Medicare paymentsPrincipal diagnosisOne-year hospitalization rateCommon principal diagnosisRisk of hospitalizationMean lengthGeneral Medicare populationMedicare paymentsPostoperative complicationsHeart failureBlack patientsMedicare patientsHospitalizationMedicare populationMedicare beneficiariesMortality ratePatientsStayCumulative daysCumulative lengthCertain subgroupsSurvivors