2017
Epidemiology, Pathophysiology, and Prognosis of Heart Failure in Older Adults
Dharmarajan K, Rich MW. Epidemiology, Pathophysiology, and Prognosis of Heart Failure in Older Adults. Heart Failure Clinics 2017, 13: 417-426. PMID: 28602363, DOI: 10.1016/j.hfc.2017.02.001.Peer-Reviewed Original ResearchConceptsHeart failureOlder adultsGeriatric syndromesHeart failure increasesCommon cardiovascular conditionAge-associated changesRehospitalization ratesCardiovascular conditionsCardiovascular syndromeCommon reasonCardiovascular structureSyndromeHospitalizationAdultsFailurePrognosisPathophysiologyDementiaFrailtyMortalityEpidemiologyPrevalenceIncidence
2016
Pathway from Delirium to Death: Potential In‐Hospital Mediators of Excess Mortality
Dharmarajan K, Swami S, Gou RY, Jones RN, Inouye SK. Pathway from Delirium to Death: Potential In‐Hospital Mediators of Excess Mortality. Journal Of The American Geriatrics Society 2016, 65: 1026-1033. PMID: 28039852, PMCID: PMC5435507, DOI: 10.1111/jgs.14743.Peer-Reviewed Original ResearchConceptsNoxious insultsIncident deliriumAssociation of deliriumDelirium prevention interventionDay of admissionHospitalized older adultsLarge academic hospitalPotential downstream mediatorsDevelopment of hospitalsUsual careHospital admissionBivariable analysisClinical trialsAcademic hospitalExcess mortalityIncreases mortalityDeliriumPrevention interventionsHigh riskPatientsMortalityInverse probabilityOlder adultsInsultDownstream mediatorTreatment for Multiple Acute Cardiopulmonary Conditions in Older Adults Hospitalized with Pneumonia, Chronic Obstructive Pulmonary Disease, or Heart Failure
Dharmarajan K, Strait KM, Tinetti ME, Lagu T, Lindenauer PK, Lynn J, Krukas MR, Ernst FR, Li SX, Krumholz HM. Treatment for Multiple Acute Cardiopulmonary Conditions in Older Adults Hospitalized with Pneumonia, Chronic Obstructive Pulmonary Disease, or Heart Failure. Journal Of The American Geriatrics Society 2016, 64: 1574-1582. PMID: 27448329, PMCID: PMC4988873, DOI: 10.1111/jgs.14303.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAgedAged, 80 and overAnti-Bacterial AgentsCardiotonic AgentsCohort StudiesComorbidityCross-Sectional StudiesDiureticsDrug Therapy, CombinationFemaleHeart FailureHospitalizationHumansMalePneumoniaPulmonary Disease, Chronic ObstructiveRetrospective StudiesUnited StatesVasodilator AgentsConceptsChronic obstructive pulmonary diseaseAcute cardiopulmonary conditionsObstructive pulmonary diseaseHeart failureCardiopulmonary conditionsOlder adultsPulmonary diseasePremier Research DatabaseEpisodes of pneumoniaRetrospective cohort studyReal-world treatmentHF hospitalizationCohort studyHospital daysPneumonia hospitalizationsCOPD hospitalizationsClinical syndromeAcute conditionsPneumoniaDiagnostic uncertaintyResearch DatabaseHospitalizationDiagnostic categoriesU.S. hospitalsAdultsMultimorbidity in Older Adults with Heart Failure
Dharmarajan K, Dunlay SM. Multimorbidity in Older Adults with Heart Failure. Clinics In Geriatric Medicine 2016, 32: 277-289. PMID: 27113146, DOI: 10.1016/j.cger.2016.01.002.Peer-Reviewed Original ResearchComprehensive Strategies to Reduce Readmissions in Older Patients With Cardiovascular Disease
Dharmarajan K. Comprehensive Strategies to Reduce Readmissions in Older Patients With Cardiovascular Disease. Canadian Journal Of Cardiology 2016, 32: 1306-1314. PMID: 27084075, DOI: 10.1016/j.cjca.2016.01.030.Peer-Reviewed Original ResearchConceptsPostacute careMultidisciplinary teamOlder adultsTransitional care interventionsShort-term readmissionCommon cardiovascular conditionSingle-center designDisease-specific careFrequent outpatientHospital dischargeOlder patientsReadmission riskReadmission reductionCardiovascular diseaseCare interventionsCardiovascular conditionsMedical conditionsHome visitsMultimodal interventionReadmissionHospital providersHealth providersCare processesMost studiesHealth system
2015
National Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010
Dodson JA, Wang Y, Murugiah K, Dharmarajan K, Cooper Z, Hashim S, Nuti SV, Spatz E, Desai N, Krumholz HM. National Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010. PLOS ONE 2015, 10: e0132470. PMID: 26147225, PMCID: PMC4493110, DOI: 10.1371/journal.pone.0132470.Peer-Reviewed Original ResearchConceptsMitral valve surgeryLength of stayHospital LOSReadmission ratesHospital readmission ratesOlder patientsHospital readmissionMedicare feeMean hospital LOSSurvival rateProportional hazards regressionYears of ageValve surgeryHazards regressionService patientsWorse outcomesAge subgroupsPatientsOlder adultsSurvivorsNational trendsReadmissionModest declineWomenSubgroups