2008
The bovine papillomavirus E5 protein and the PDGF β receptor: It takes two to tango
Talbert-Slagle K, DiMaio D. The bovine papillomavirus E5 protein and the PDGF β receptor: It takes two to tango. Virology 2008, 384: 345-351. PMID: 18990418, PMCID: PMC2661243, DOI: 10.1016/j.virol.2008.09.033.Peer-Reviewed Original ResearchConceptsBovine papillomavirus E5 proteinE5 proteinTransmembrane domainTransmembrane proteinTarget proteinsPlatelet-derived growth factor beta receptorArtificial transmembrane proteinsMembrane-spanning segmentsHuman erythropoietin receptorBPV E5 proteinGrowth factor beta receptorCellular receptor tyrosine kinasesLigand-independent activationReceptor tyrosine kinasesGenetic screenPDGF β-receptorNovel proteinTransmembrane sequenceCellular proteinsMitogenic signalingHydrophobic proteinsReceptor dimerizationLarger target proteinsErythropoietin receptorSmall proteins
2005
Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT
Choi J, Walker J, Talbert-Slagle K, Wright P, Pober JS, Alexander L. Endothelial Cells Promote Human Immunodeficiency Virus Replication in Nondividing Memory T Cells via Nef-, Vpr-, and T-Cell Receptor-Dependent Activation of NFAT. Journal Of Virology 2005, 79: 11194-11204. PMID: 16103171, PMCID: PMC1193601, DOI: 10.1128/jvi.79.17.11194-11204.2005.Peer-Reviewed Original ResearchConceptsMemory T cellsHuman immunodeficiency virus (HIV) replicationImmunodeficiency virus replicationT cellsViral replicationEndothelial cellsAntiretroviral therapyHIV replicationSuboptimal T cell receptor (TCR) stimulationHIV Type 1 ReplicationVirus replicationMajor histocompatibility complex (MHC) class II moleculesType 1 replicationTumor necrosis factorMHC class IIClass II moleculesT cell receptor stimulationVirus-producing cellsReceptor-dependent activationNef-dependent mannerEffector cytokinesHuman endothelial cellsHLA-DRIL-6Presence of EC