2013
A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor*
Petti LM, Talbert-Slagle K, Hochstrasser ML, DiMaio D. A Single Amino Acid Substitution Converts a Transmembrane Protein Activator of the Platelet-derived Growth Factor β Receptor into an Inhibitor*. Journal Of Biological Chemistry 2013, 288: 27273-27286. PMID: 23908351, PMCID: PMC3779723, DOI: 10.1074/jbc.m113.470054.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBovine papillomavirus 1CattleCell LineCell Transformation, ViralEnzyme ActivatorsFibroblastsHumansMaleMiceMutation, MissenseOncogene Proteins v-sisOncogene Proteins, ViralPhosphorylationProtein Kinase InhibitorsReceptor, Platelet-Derived Growth Factor betaSignal TransductionConceptsTransmembrane domainTransmembrane proteinPlatelet-derived growth factor β receptorLimited sequence similarityGrowth factor β receptorParticular tyrosine residueLigand-independent mannerSequence similarityGenetic evidenceGrowth factor receptorE5 proteinOncogenic transformationWild typeProtein activatorViral homologueTyrosine residuesE5 bindsProtein inhibitorPDGFβRV-sisPDGFβ receptorBovine papillomavirusFactor receptorNonidentical sitesCell proliferation
2008
The bovine papillomavirus E5 protein and the PDGF β receptor: It takes two to tango
Talbert-Slagle K, DiMaio D. The bovine papillomavirus E5 protein and the PDGF β receptor: It takes two to tango. Virology 2008, 384: 345-351. PMID: 18990418, PMCID: PMC2661243, DOI: 10.1016/j.virol.2008.09.033.Peer-Reviewed Original ResearchConceptsBovine papillomavirus E5 proteinE5 proteinTransmembrane domainTransmembrane proteinTarget proteinsPlatelet-derived growth factor beta receptorArtificial transmembrane proteinsMembrane-spanning segmentsHuman erythropoietin receptorBPV E5 proteinGrowth factor beta receptorCellular receptor tyrosine kinasesLigand-independent activationReceptor tyrosine kinasesGenetic screenPDGF β-receptorNovel proteinTransmembrane sequenceCellular proteinsMitogenic signalingHydrophobic proteinsReceptor dimerizationLarger target proteinsErythropoietin receptorSmall proteins